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Diagnoses Disease clinical trials

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NCT ID: NCT03968016 Completed - Diagnoses Disease Clinical Trials

Reference Interval Validation of High-Sensitivity Cardiac Troponin T Assay in Thai Population

Start date: January 27, 2019
Phase: N/A
Study type: Interventional

The investigators aimed to study the cut-off of high sensitivity troponin T using SYSMEX HLSCL Machine in Thai population at percentile 99.

NCT ID: NCT03967652 Not yet recruiting - Cancer Clinical Trials

Cancer Diagnoses From Exhaled Breath With Na-nose

Start date: July 1, 2019
Phase:
Study type: Observational

Early diagnoses of malignant tumors are pivotal for improving their prognoses. The Exhaled Breath is made up of oxygen, carbon dioxide, nitrogen, water, inert gases and volatile organic compounds (VOCs). Theoretically, the concentration of VOCs in exhalation produced by metabolism in human body is only about nmol/L-pmol/L, which can significantly increase under certain pathological conditions. A series of studies of VOCs diagnosing solid tumors the investigators had been conducted in the past decade. It was found that VOCs in exhaled breath can not only distinguish different types of tumors, but also can make a clear distinction between different stages. Our long-term collaborator, Professor Hossam Haick (Israel Institute of Technology) has developed a nano sensor array, so called Na-nose, which can detect VOCs of the exhaled breath by binding gases to specific chemiresistors coated with gold nanomaterials. The Na-nose has the advantages of low cost, easy to use, good reproducibility and real-time detection for large scale clinical application. This study was to use large clinical samples to validate the diagnostic efficacy of the newly developed Nano-nose( Sniffphone and Breath Screener) for malignant tumors .

NCT ID: NCT03958812 Not yet recruiting - Breast Cancer Clinical Trials

Diagnostic Power Comparison Between VOCs and CTCs

Start date: June 15, 2019
Phase:
Study type: Observational

Early diagnosis of malignant tumors is pivotal for improving their prognoses. Circulating tumor cells (CTC) in peripheral blood and Volatile organic compounds (VOCs) in exhaled breath are newly developed diagnosis method. Due to the low percentage of CTCs in peripheral blood of cancer patients and the surface structure of lymphocytes (especially megakaryocytes) is often confused with tumor cells, CTC has a high false positive and negative rate. In recent years, the detection of volatile organic compounds (VOCs) in exhaled breath as a simple and noninvasive method has shown broad application prospects in the diagnosis of various diseases. A series of studies of VOCs diagnosing solid tumors the investigators had conducted in the past decade show that VOCs can not only distinguish different types of tumors, but also can make a distinction between different stages. This study was to compare CTC and VOCs with clinical samples. Predictive models will be built employing discriminant factor analysis (DFA) pattern recognition method. Sensitivity and specificity will be determined using leave-one-out cross-validation or an independent blind test set.

NCT ID: NCT03938376 Completed - Diagnoses Disease Clinical Trials

Micro-Ultrasound/Magnetic Resonance Imaging 001

Start date: May 24, 2019
Phase:
Study type: Observational

Micro-ultrasound is a novel real-time imaging modality which maintains the clinical workflow of conventional ultrasound-guided prostate biopsy, while potentially maintaining a similar ability to detect clinically significant prostate cancer (csPCa) to MRI. This prospective trial aims to compare micro-ultrasound to mpMRI in detection of csPCa in the biopsy naïve.

NCT ID: NCT03895177 Active, not recruiting - Diagnoses Disease Clinical Trials

Evaluation of Resectability of Pancreatic Cancer Using Low kVp CT

Start date: March 12, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to investigate usefulness of low kVp high mAs computed tomography in evaluation of pancreatic cancer resectability.

NCT ID: NCT03772496 Recruiting - Diagnoses Disease Clinical Trials

Diagnostic Significance of CTCs in Patients With Thyroid Nodules (Circulating Tumor Cells)

CTCs
Start date: July 25, 2018
Phase: N/A
Study type: Interventional

Thyroid nodule patients with suggestion of fine needle aspiration biopsy (FNAB) offered by ultrasound are enrolled in the study. CTCs tested by Optimizing method and FNAB will be performed simultaneously. This is a double blind trial which pathologists and inspectors of CTCs don't know the result of each other. Surgical pathology and diagnostic results of FNAB is the primary endpoint and comparison will be made to see if CTCs combined with ultrasound can get similar diagnostic performance as FNAB. The diagnostic results of FNAB included Bethesda class II and more than V which are defined as benign and malignant, respectively.

NCT ID: NCT03759470 Not yet recruiting - Diagnoses Disease Clinical Trials

Evaluation of Different Methods for Diagnosis of ME

Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

Bacterial meningitis occurs in about 3 people per 100,000 annually in Western countries. .

NCT ID: NCT03734172 Completed - Tuberculosis Clinical Trials

Rapid and Accurate Diagnosis of Paediatric TB (RaPaed-AIDA-TB)

RaPaed
Start date: January 21, 2019
Phase:
Study type: Observational

This study will serve as a platform to evaluate new diagnostics in children suspected to have TB, establish diagnostic performance (sensitivity and specificity) and calculate positive and negative predictive values in a real-life cohort. Finally, this study will comprise the results of several tests in its database. This will allow simulation of diagnostic algorithms, that may be composed of screening (i.e. rule-out) tests together with confirmatory tests to maximize sensitivity and specificity.

NCT ID: NCT03725709 Completed - Clinical trials for Diabetes Mellitus, Type 2

Metabolomic Profiling of in Patients With type2 Diabetes

Start date: August 1, 2016
Phase:
Study type: Observational

To exam the metabolomic profiling of CSF and plasma in diabetes and establish the human CSF Metabolome Database of Type 2 DM.

NCT ID: NCT03690479 Completed - Periodontitis Clinical Trials

The Impact of a Modified Probe Tip Design on Patient Perception of Discomfort on Probing and Clinical Parameters Using the Florida Probe® System

Start date: April 4, 2013
Phase: N/A
Study type: Interventional

Patient perception of pain on periodontal probing using a controlled-force, electronic probe was not significantly affected by the use of a modified (ball-end) probe tip design except for in the maxilla, where a standard straight probe tip appeared to be more comfortable for patients.