Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Maximizing Postprandial Glycaemic Control: When is the Right Time for Physical Activity
Verified date | December 2018 |
Source | University of Birmingham |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Physical activity helps maintain optimal postprandial blood glucose control. However, there is a lack of clear information regarding the optimal meal-activity timing required to maximize blood glucose control. By using continuous glucose monitoring (CGM), this randomized controlled trial will determine whether implementing a bout of physical activity immediately before, or immediately after, or shortly after a meal is most optimal. This study will also independently examine the effects of three different physical activities: walking, standing, and circuit-exercises. Minimizing the changes in blood glucose following a meal not only reduces the risk of type 2 diabetes but also reduces cardiovascular-related mortality. Therefore, the data produced by this project will have very important implications for informing healthcare policy and physical activity recommendations.
Status | Completed |
Enrollment | 48 |
Est. completion date | December 8, 2018 |
Est. primary completion date | November 9, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Age 18-65 years. - Body Mass Index 18-30 kg/m2. - Generally healthy. Exclusion Criteria: - Smoking. - Pregnancy, or planning to become pregnant, or a nursing mother. - More than 2 kg weight change during the last month. - Diabetes. - Evidence of, or being treated for, cancer or infectious/non-infectious chronic hematological, pulmonary, cardiac, hepatic, renal, or gastrointestinal diseases. - Any contraindication to exercise |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Birmingham | Edgbaston | West Midlands |
Lead Sponsor | Collaborator |
---|---|
University of Birmingham |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postprandial blood glucose concentrations. | Continuous glucose monitoring (CGM; Dexcom G5 Mobile) will be used to measure the change in glucose levels from baseline. | In all trials, postprandial blood glucose concentrations will be measured - the change from baseline (immediately prior to meal ingestion) 2-hours after meal ingestion. | |
Secondary | Postprandial blood glucose control (mean). | Mean glucose levels will be derived from CGM-measurements. | In all trials, postprandial glucose control will be measured between baseline (immediately prior to meal ingestion) and the end of the trial (2-hours after meal ingestion). | |
Secondary | Postprandial blood glucose control (standard deviation). | The standard deviation of glucose levels will be derived from CGM-measurements. | In all trials, postprandial glucose control will be measured between baseline (immediately prior to meal ingestion) and the end of the trial (2-hours after meal ingestion). | |
Secondary | Postprandial blood glucose control. | The mean amplitude of glycemic excursions will be derived from CGM-measurements. | In all trials, postprandial glucose control will be measured between baseline (immediately prior to meal ingestion) and the end of the trial (2-hours after meal ingestion). |
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