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Metformin and Congenital Nephrogenic Diabetes Insipidus

Diabetes Insipidus Clinical Trial

Official title:
Use of Metformin to Treat Patients With Congenital Nephrogenic Diabetes Insipidus (NDI)

Clinical Trial Summary

The purpose of this study is to determine whether metformin can increase urine concentration (osmolality) and decrease the amount of urine in patients with congenital nephrogenic diabetes insipidus (NDI).

Clinical Trial Description

Nephrogenic diabetes insipidus (NDI) is a genetic disease. Patients with this disease make large amounts of urine because their kidneys don't hold on to water. The large amount of urine means that patients need to urinate very frequently. They are also at increased risk for dehydration if they don't drink enough. The large amount of urine can sometimes damage their bladders and kidneys. There are some medicines that may help these patients urinate less, but they are not very effective. There is evidence in animal studies that a medication called metformin may help patients with NDI urinate less. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02460354
Study type Interventional
Source Emory University
Contact
Status Terminated
Phase Phase 1
Start date September 2015
Completion date June 2017
View Details
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