Diabetes Clinical Trial
Official title:
Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus and the Effect of Dexmedetomidine on the Stress Response in Patients With Diabetic Undergoing Gastric-bypass Surgery
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and intravenous anesthesia on stress reactions generated by patients with diabetes conducted gastric - bypass surgery , and choose a best way from three kinds of anesthesia to control stress reaction of diabetics. After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.
Research content and indicators
1. Preparation of serum: 3ml of blood were taken before induction of anesthesia (after
entering the operating room), surgery began 1h, surgery began 2h, 24h after surgery,
and placed at dry tube, centrifuged for 10min at 3000g after placing at room
temperature for 2h , the resulting supernatant was subpassaged in tube, stored at -20℃
until analysis.
2. Indicators to detect in serum contained Tumor Necrosis Factor-α, Interleukin-6,
Interleukin-10, plasma glucose, cortisol,insulin and c-peptide.
3. Record the vital signs.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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