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NCT00004364 Clinical Trial

Study of Novel Types of Familial Diabetes Insipidus

Diabetes Insipidus Clinical Trial

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT00004364
Other study ID # 199/11939
Secondary ID NU-570
Status Active, not recruiting
Phase N/A
First received October 18, 1999
Last updated February 21, 2006
Start date December 1995

Study information
Verified date February 2006
Source Office of Rare Diseases (ORD)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

OBJECTIVES:

I. Define the phenotype and genotype of previously unrecognized types of familial diabetes insipidus (FDI) in kindreds with atypical or novel forms of FDI.

Description:

PROTOCOL OUTLINE: Participants undergo a series of tests to determine the presence, absence, cause, natural history, clinical status, and mode of inheritance of their type of diabetes insipidus (DI). The studies include measurements of basal fluid intake and urine output, plasma vasopressin during standard fluid deprivation or waterload/saline infusion tests, and changes in water balance during a therapeutic trial of DDAVP. If clinically indicated, echocardiograms and assays of plasma catecholes and renin are also completed.

Linkage analysis is performed for all participants; kindreds with the Marfan-like syndrome are also studied for the fibrillin-1 genotype.

Participants determined to have DI are treated with desmopressin for 2 days.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 5
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 6 Months to 70 Years
Eligibility - Familial diabetes insipidus (DI) in atypical or novel form, e.g.: Dipsogenic DI Neurohypophyseal DI

- Affected and unaffected members of kindreds eligible

Study Design

Primary Purpose: Screening

Related Conditions & MeSH terms

Intervention

Drug:
• desmopressin

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
National Center for Research Resources (NCRR) Northwestern University
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