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Glucagon Responses During Oral- and iv Glucose in Patients With Type 1 Diabetes

Diabetes Mellitus Clinical Trial

Official title:
Glucagon Responses Following Oral Glucose and Isoglycemic iv Glucose in Patients With Type 1 Diabetes - a Role for the Gastrointestinal Tract in Diabetic Hyperglucagonemia?

Clinical Trial Summary

In order to evaluate the potential role of the gastrointestinal (GI) tract in the postprandial hyperglucagonemia, which characterizes type 1 diabetes mellitus (T1DM) (as well as type 2 diabetes mellitus (T2DM)), we wish to investigate the secretion of glucagon in patients with T1DM without residual beta-cell function during 50-g oral glucose tolerance test (OGTT) and during isoglycemic iv glucose infusion. By evaluating C-peptide negative patients with T1DM we aim to describe the glucagon response to glucose (+/-stimulation of the GI tract) independently of the potentially very important regulation of glucagon secretion by endogenous insulin secretion. A more detailed understanding of the inappropriate glucagon secretion in T1DM is highly needed in order to establish new intervention strategies in the future treatment of the growing numbers of T1DM patients.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00704795
Study type Observational
Source University Hospital, Gentofte, Copenhagen
Contact
Status Active, not recruiting
Phase N/A
Start date June 2008
Completion date October 2009
View Details
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