Diabetes Mellitus, Type 2 Clinical Trial
Official title:
The Effects of Iloprost Infusion on Capillary Recruitment and Whole-body Glucose Uptake in Type 2 Diabetic Patients - a Cross-over Trial.
This study examines the effects of iloprost - a stable prostacyclin analogue - on insulin-mediated muscle capillary recruitment and whole-body glucose uptake in a cross-over design.
In type 2 diabetes impaired insulin-mediated muscle perfusion is thought to contribute to
reduced whole-body glucose uptake. This study aims to identify iloprost - a stable
prostacyclin analogue - as a possible therapeutic option to increase whole-body glucose
uptake via enhancement of muscle perfusion.
All participants will be subjected to two hyperinsulinemic-euglycemic clamps; one with and
one without simultaneous iloprost infusion in a randomized cross-over design. Microvascular
blood volume will be measured by means of contrast-enhanced ultrasonography.
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