Diabetes Mellitus, Type 2 Clinical Trial
Official title:
SGLT2 Inhibition in Diabetic Patients With Heart Failure With Reduced Ejection Fraction
To determine the effects of SGLT2 inhibition with empagliflozin on cardio-respiratory fitness in patients with systolic heart failure.
The investigators hypothesize that Sodium-GLucose coTransporters (SGLT)-2 inhibition will
improve cardio-respiratory fitness (CRF) in patients with systolic heart failure.
Participants treated with SGLT2 inhibitor Empagliflozin as standard of care will undergo
assessments described below.
The investigators will measure CRF with a validated cardiopulmonary exercise test at baseline
and after 4 weeks of treatment received as standard of care, to determine whether SGLT2
inhibition improves cardio-respiratory fitness assessed by changes in peak oxygen consumption
(VO2)(mL/kg/min) and minute ventilation (VE)/carbon dioxide production (VCO2) slope, powerful
independent clinical predictors of mortality in HF.
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