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Dexmedetomidine clinical trials

View clinical trials related to Dexmedetomidine.

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NCT ID: NCT03632330 Completed - Sedation Clinical Trials

Sedation Of Adult Patients Undergoing Gastrointestinal Endoscopy: A Network Meta-analysis

Start date: February 5, 2018
Phase:
Study type: Observational

The objective of this study is to compare the efficacy and safety of dexmedetomidine with other sedatives in sedation during endoscopy by analyzing the most recently published interventional trials and observational studies.

NCT ID: NCT03629483 Suspended - Elderly Clinical Trials

Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block

Start date: December 10, 2018
Phase: Phase 4
Study type: Interventional

Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. Continuous femoral nerve block is frequently used for postoperative analgesia after total knee arthoplasty. The investigators hypothesize that dexmedetomidine, when combined with ropivacaine for continuous femoral nerve block, can reduce the incidence of delirium and improve the long-term outcome in elderly patients after total knee arthroplasty.

NCT ID: NCT03629262 Active, not recruiting - Analgesia Clinical Trials

Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery

Start date: October 28, 2018
Phase: Phase 4
Study type: Interventional

Delirium is common in the elderly after orthopedic surgery and is associated with worse outcomes. The investigators hypothesize that, for elderly patients after orthopedic surgery, dexmedetomidine supplemented intravenous analgesia can reduce the incidence of delirium and improve the long-term outcomes.

NCT ID: NCT03624595 Active, not recruiting - Delirium Clinical Trials

Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery

Start date: April 16, 2019
Phase: N/A
Study type: Interventional

Delirium is an acutely occurred and fluctuating cerebral dysfunction characterized with inattention, altered consciousness, cognitive decline and/or abnormal perception. It is common in the elderly after cardiac surgery and is associated with worse outcomes. Causes leading to delirium are multifactorial but sleep disturbances remains an important one. In previous studies, sedative-dose dexmedetomidine improves sleep quality in ICU patients with mechanical ventilation; and low-dose dexmedetomidine improves sleep quality in postoperative patients without mechanical ventilation. In recent studies of elderly after noncardiac surgery, night-time infusion of low-dose dexmedetomidine reduces delirium and improves 2-year survival. The investigators hypothesize that, for elderly patients after cardiac surgery, night-time infusion of dexmedetomidine may also improve sleep quality, reduce delirium development and improve 2-year survival.

NCT ID: NCT03480061 Active, not recruiting - Depression Clinical Trials

Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery

Start date: August 9, 2018
Phase: Phase 4
Study type: Interventional

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive dysfunction (POCD). These cognitive deficits are associated with increased mortality, prolonged hospital stay and loss of independence. The investigators propose to investigate the role of Dexmedetomidine (DEX) in preventing long-term POCD after cardiac surgery and enhancing early postoperative recovery. It is anticipated that DEX will be the first effective preventative therapy for POCD, improve patient outcomes, and reduce length of stay and healthcare costs.

NCT ID: NCT03479216 Completed - Postoperative Pain Clinical Trials

Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain

Start date: March 26, 2018
Phase: Phase 4
Study type: Interventional

Arthroscopic meniscus surgeries are the most frequent orthopedic procedures. The objective of the study is to compare the effects of intraarticular local anesthetic and adjuvant (dexmedetomidine vs magnesium) combinations in postoperative pain and analgesic requirement. The investigators' hypothesis is adjuvants added to the local anesthetics decreases the total local anesthetic dose, provides more effective pain relief according to local anesthetic only, and decreases the postoperative systemic non-steroidal analgesic and opioid doses.

NCT ID: NCT03436472 Completed - Delirium Clinical Trials

Dexmedetomidine and 5-year Outcome in Elderly Patients After Surgery

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

Delirium is a frequent postoperative complication. Its occurrence is associated with worse long-term outcomes. In a previous randomized controlled trial, prophylactic low-dose dexmedetomidine infusion during the early postoperative period decreased the incidence of delirium in elderly patients after surgery. The purpose of this 5-year follow-up study is to evaluate whether prophylactic low-dose dexmedetomidine infusion can improve the 5-year outcomes in elderly patients recruited in the previous randomized controlled trial.

NCT ID: NCT03417999 Terminated - Clinical trials for Congenital Heart Disease

Pharmacokinetic Study of Intranasal Dexmedetomidine in Pediatric Patients With Congenital Heart Disease

Start date: June 14, 2018
Phase: Phase 1
Study type: Interventional

The main objectives of the study are to determine peak plasma drug concentration levels and corresponding time of dexmedetomidine following intranasal administration in children age ≥1 mo to ≤ 6 yr with congenital heart disease undergoing an elective diagnostic or interventional cardiac catheterization procedure.

NCT ID: NCT03337581 Recruiting - Pharmacokinetics Clinical Trials

Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric

Start date: October 20, 2017
Phase: Phase 4
Study type: Interventional

1. Acute Hemodynamic and respiratory Changes After Rapid Intravenous different doses of Dexmedetomidine in Pediatric. 2. Pharmacokinetics after a single Rapid Intravenous dose of Dexmedetomidine in Pediatric. 3. Pharmacokinetics after a single dose of Dexmedetomidine administered as a nasal spray in Pediatric.

NCT ID: NCT03335527 Completed - Clinical trials for Mechanical Ventilation Complication

Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients

Start date: November 17, 2017
Phase: Phase 4
Study type: Interventional

Sleep disturbances frequently occur in intensive care unit (ICU) patients undergoing mechanical ventilation. In a previous study, sedative dose dexmedetomidine (median 0.6 microgram/kg/h) improved sleep quality in mechanically ventilated patients. However, for mechanically ventilated patients, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased mortality. In a recent study of the investigators, non-sedative low-dose dexmedetomidine (0.1 microgram/kg/h) improved sleep quality in non-mechanically ventilated elderly patients admitted to the ICU after surgery. The investigators hypothesize that, in mechanically ventilated patients who are admitted to the ICU after surgery, low-dose dexmedetomidine may also improve sleep quality.