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Clinical Trial Summary

We will study whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain (cLBP) with or without mild-to-moderate depression.

Clinical Trial Description

We will conduct a randomized, double-blind, 2-arm mechanistic trial to assess the effects of CBD and placebo in patients with cLBP with and without mild-to-moderate depression, using integrated positron emission tomography / magnetic resonance imaging (PET/MRI) scans. The use of integrated PET/MRI will allow us to simultaneously evaluate neuroinflammation (using [11C]PBR28, a second-generation radioligand for TSPO) and striatal function (using the Monetary Incentive Delay task, a validated fMRI task that probes behavioral and neural responses to rewards and losses). ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05066308
Study type Interventional
Source Massachusetts General Hospital
Contact Jodi M Gilman, PhD
Phone 617-643-7293
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date October 1, 2021
Completion date December 15, 2026

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