Depression Clinical Trial
Official title:
Rational Optimization of tACS for Targeting Thalamo-Cortical Oscillations (Experiment 3)
Purpose: Investigating the effects of non-invasive transcranial alternating current
stimulation (tACS) on healthy participants and participants with mood disorders.
Participants: 40 males and females, ages 18-65, with depressed mood; 40 healthy males and
females, ages 18-65, free of neurological or psychiatric conditions.
Procedures: This is a single visit study with two stimulation conditions (tACS and sham
tACS). The session will begin with clinical assessments (including confirmation of
diagnosis), followed by an interactive EEG task, then a 7 minute resting state EEG (2 minutes
eyes closed, 5 minutes eyes open), followed by the stimulation session (40 minutes of tACS or
sham tACS), followed by an additional 5 minute resting state EEG. The stimulation will
involved 40 minutes of transcranial alternating current stimulation, 2 mA in amplitude and at
individualized alpha frequency (determined by the 2 minutes eyes closed EEG recording;
between 8 and 12Hz).
Participants will report for a study visit and will review and sign a consent form.
Participants will complete several clinical assessments and also take a urine drug test and
urine pregnancy test (if applicable). Eligibility will be re-assessed by the investigators
before the participant moves on to the next phase.
If the participant still qualifies, the participant will first be fitted with two 5x5cm
electrodes placed over F3/F4 (10-20 measurement system) and one 5x7cm electrode placed over
Cz. In addition, the participant will have a 128-channel EEG net placed on their head.
Participants will provide a saliva sample to assess for brain-derived neurotrophic factor
(BDNF), which may affect how the participant's brain responds to stimulation. Once the
participant is fitted with this equipment, the participant will complete two interactive EEG
tasks, then 2-minute resting state EEG with the participant's eyes closed, then a 5-minute
resting state EEG with the participant's eyes open.
Following these recordings, participants will respond to additional questionnaires.
Immediately following this, the participant will receive 40 minutes of stimulation (tACS or
sham tACS). During this stimulation, participants will sit comfortably upright and awake.
After stimulation has completed, participants will respond to additional questionnaires. Once
completed, participants will then complete an additional 5-minute resting state EEG with the
participant's eyes open, as well as complete one of the additional interactive EEG tasks.
Finally, participants will respond to a blinding questionnaire to assess if the participant
thought that the participant received stimulation. Once complete, the participant will leave.
This session is estimated to last about 4 hours.
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