Depressive Disorder Clinical Trial
Official title:
Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression
NCT number | NCT02741622 |
Other study ID # | 2015/2230 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | March 2016 |
Est. completion date | December 2016 |
Verified date | December 2018 |
Source | St. Olavs Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain
derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the
affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity
dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the
maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients
with depression.
The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity
training and long-slow-distance training in a intra-individual design in patients suffering
from depression. The results will give indications of a possible difference in BDNF response
between aerobic intensities and may be uses as pilot data for calculating sample size.
Status | Completed |
Enrollment | 21 |
Est. completion date | December 2016 |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Moderate or severe depression (ICD10: F32-F33) Exclusion Criteria: - Bipolar disorder. |
Country | Name | City | State |
---|---|---|---|
Norway | St.Olavs university Hospital, Departement of Østmarka | Trondheim |
Lead Sponsor | Collaborator |
---|---|
St. Olavs Hospital | Norwegian University of Science and Technology |
Norway,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in serum brain derived neurotropic factor (BDNF) | To measure serum BDNF levels, blood samples will be taken before and after each workout session. | 15 minutes before exercise to 5> minutes after exercise. | |
Secondary | Change in affective symptoms | The positive and negative affect schedule (PANAS) . | 15 minutes before exercise to 15> minutes after exercise. | |
Secondary | Change in state of anxiety. | A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety. | 15 minutes before exercise and 15> minutes after exercise. | |
Secondary | Change in subjective exercise experience | The Subjective exercise experience scale (SEES). | 15 minutes before exercise to 15> minutes after exercise. | |
Secondary | Maximal oxygen uptake | Baseline | ||
Secondary | Maximal Heart rate | Baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01316926 -
Paxil CR Bioequivalence Study Brazil
|
Phase 1 | |
Recruiting |
NCT06187454 -
Transcranial Direct Current Stimulation for Depression
|
N/A | |
Completed |
NCT04469322 -
Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory Depression
|
N/A | |
Recruiting |
NCT05768126 -
Prediction of ECT Treatment Response and Reduction of Cognitive Side-effects Using EEG and Rivastigmine
|
Phase 4 | |
Completed |
NCT03219879 -
Telephone-administered Relapse Prevention for Depression
|
N/A | |
Recruiting |
NCT06038721 -
Unified Protocol: Community Connections
|
N/A | |
Completed |
NCT03043560 -
Study to Treat Major Depressive Disorder With a New Medication
|
Phase 2 | |
Completed |
NCT04091139 -
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
|
Phase 2/Phase 3 | |
Completed |
NCT00069459 -
Seasonal Affective Depression (SAD) Study
|
Phase 1 | |
Recruiting |
NCT05503966 -
Combining Antidepressants and Attention Bias Modification in Depression
|
N/A | |
Recruiting |
NCT03001245 -
Interpersonal Counseling (IPC) for Treatment of Depression in Adolescents
|
N/A | |
Completed |
NCT02939560 -
TMS for Adults With Autism and Depression
|
N/A | |
Completed |
NCT02452892 -
Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
|
N/A | |
Completed |
NCT02542891 -
European Comparative Effectiveness Research on Internet-based Depression Treatment
|
N/A | |
Completed |
NCT02306551 -
Well Being And Resilience: Mechanisms of Transmission of Health and Risk
|
||
Withdrawn |
NCT02238730 -
Ultrabrief Right Unilateral and Brief Pulse Bitemporal Electroconvulsive Therapy
|
N/A | |
Completed |
NCT02224508 -
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
|
N/A | |
Completed |
NCT01407575 -
Buprenorphine for Treatment Resistant Depression
|
Phase 3 | |
Completed |
NCT01597661 -
Bupropion & Cardio Birth Defect (Slone)
|
N/A | |
Completed |
NCT01093053 -
Mind-Body Skills Groups for the Treatment of War Zone Stress in Military and Veteran Populations
|
N/A |