Depressive Disorder Clinical Trial
Official title:
Validation of Individualized rTMS Protocol Using Non Invasive Functional Brain Imaging and Robotic Coil Placement in Resistant Depression: Comparison With Classical rTMS and tDCS
Although repetitive trans-cranial magnetic stimulation (rTMS) is an effective therapy for
resistant depression, it still fail to remit up to 70% of these patients. We hypothesize
that personalizing the procedure using functional MRI to better select dysfunctional regions
and robotic coil placement to stimulate these regions homogeneously, will increase its
efficacy. Individualized rTMS will be compared to traditional rTMS procedure and to
trans-cranial direct current stimulation (tDCS).
In this small proof of principle study our primary outcome measure will be the correction of
the MRI anomalies. Symptoms reduction and the proportion of remitters will be secondary
outcome measurements.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Treatment
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