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NCT00488670 Clinical Trial

Escitalopram and Depression in Elderly Alzheimer's Patients

Depressive Disorder Clinical Trial

Official title:
An Open-label Study of Escitalopram in the Treatment of Major Depressive Disorder in Elderly Patients With Alzheimer's Disease

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT00488670
Other study ID # H07-00050
Secondary ID
Status Terminated
Phase Phase 3
First received June 18, 2007
Last updated June 2, 2011
Start date December 2010
Est. completion date June 2011

Study information
Verified date June 2011
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority Canada: Health Canada
Study type Interventional

Clinical Trial Summary

To investigate the effect of Escitalopram in a large and diverse of dementia patients suffering from depression.

Description:

This study will assess the efficacy, tolerability, and safety of escitalopram in the treatment of Major Depressive Disorder in patients with Alzheimer's disease over a 24-week period. It will also assess the efficacy and tolerability of escitalopram after 12 weeks of treatment.

Recruitment information / eligibility
Status Terminated
Enrollment 50
Est. completion date June 2011
Est. primary completion date June 2011
Accepts healthy volunteers No
Gender Both
Age group 50 Years and older
Eligibility Inclusion Criteria:

- > 50 years

- Male & female

- Alzheimer's disease

- Depressive episode

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Escitalopram
See Detailed Description.

Locations
Country Name City State
Canada Mt. St. Joseph's Hospital Vancouver British Columbia
Canada Vancouver General Hospital Vancouver British Columbia

Sponsors (1)
Lead Sponsor Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in Cornell Scale for Depression in Dementia (CSDD) from baseline. Unspecified No
Secondary Montgomery-Åsberg Depression Rating Scale; Neuropsychiatric Inventory; Alzheimer's Disease Cooperative Study Unspecified No
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