Depressive Disorder, Major Clinical Trial
Official title:
The Role Of Omega-3 Fatty Acids In Adolescent Depression
The purpose of this study is to examine the effects of a 10-week Omega-3 Fatty Acid treatment phase on brain chemistry of adolescents with major depressive disorder (MDD) using proton magnetic resonance imaging.
This study rests on a confluence of findings showing that: 1) Major depressive disorder
(MDD), is a major public health concern that often emerges in adolescence; which entails 2)
pathophysiological abnormalities in fronto-striatal structures resulting in death and atrophy
of glia and neurons; 3) omega-3 fatty acids (FA) effects on brain function in adolescent MDD
can be assessed by proton magnetic resonance spectroscopy (1H MRS); and, 4) it is critical
that commonly used complementary and alternative medicines such as omega-3FA that have face
validity be tested for their neurobiological effect in MDD.
Using 1H MRSI, this study examines the effects of Omega-3FA on striatal and anterior
cingulate cortex (ACC) concentrations of the neurocellular biomarkers total choline (tCho),
total creatine (tCr), and γ-aminobutyric acid (GABA, ACC only) in adolescent MDD. Hypotheses
are: 1) relative to placebo, omega-3FA treatment will result in significant reductions of
striatal and ACC tCho and tCr concentrations, and increased ACC GABA; 2: Regardless of
treatment condition (placebo or Omega-3FA), MDD adolescents who are improved at the end of
10-week treatment will exhibit a significant decrease in striatal and ACC tCho and tCr
concentrations, and increases in ACC GABA relative to unimproved adolescents.
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