Depressive Disorder, Major Clinical Trial
Official title:
Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression
Depression is the most common psychiatric disorder.
- 3-5% of a given population has major depression.
- Less than 50% of the depressed in Denmark are diagnosed with major depression.
- 25-50% of the depressed have a relative with major depression-underlying brain
pathology?
The purpose of this study is to use MRI to evaluate cerebral morphology and function in
ambulant patients with major depression
Previous studies within major depression, have often included hospitalized patients with
severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing
radiation. This study focus on ambulant patients(with or without medication/ECT treatment),
to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin
Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry
with BRAVO 3D T1 ax will be performed.
MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.
;
Observational Model: Case-Only, Time Perspective: Prospective
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