A Study of GW856553X For the Treatment of Depression

Status Terminated

Clinical Trial Summary

GW856553 is a novel compound, currently in development for the treatment of Major Depressive Disorder (MDD), and other indications. GW856553 inhibits a protein which is responsible for the production of some pro-inflammatory molecules, called cytokines. Increased blood levels of these molecules were seen in populations of MDD patients and this was more apparent in subjects with severe symptoms, psychomotor retardation and loss of energy. Aim of the present study is to assess whether GW856553, by inactivating this protein, is able to suppress the production of the cytokines, and ultimately relieving depression symptoms. In this study GW856553 or placebo is given to MDD patients 7.5md twice daily for 6 weeks.

Clinical Trial Description

A randomised, double-blind, placebo-controlled study to explore the antidepressant properties of the P38a kinase inhibitor GW856553X 15mg compared to placebo in subjects with Major Depressive Disorder exhibiting symptoms of loss of energy and interest, and psychomotor retardation, for a six week treatment period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00569062
Study type	Interventional
Source	GlaxoSmithKline
Contact
Status	Terminated
Phase	Phase 2
Start date	September 12, 2007
Completion date	June 25, 2008

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05915013` - Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response	Phase 1
Completed	`NCT04469322` - Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory Depression	N/A
Recruiting	`NCT05415397` - Treating Immuno-metabolic Depression With Anti-inflammatory Drugs	Phase 3
Recruiting	`NCT05988333` - Psychoeducational Intervention for Families With a Member Affected by Major Depression	N/A
Completed	`NCT02919501` - Study of the Efficacy and Safety of Initial Administration of 17 mg Vortioxetine Intravenously With 10 mg/Day Vortioxetine Orally in Patients With Major Depressive Disorder	Phase 2
Completed	`NCT00976560` - Clinical Study to Test a New Drug to Treat Major Depression	Phase 2
Recruiting	`NCT05518149` - A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)	Phase 3
Not yet recruiting	`NCT06303076` - Tizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trial	Phase 4
Not yet recruiting	`NCT05901571` - Acupuncture and Escitalopram for Treating Major Depression Clinical Study	N/A
Suspended	`NCT02546024` - Predictors of Treatment Response in Late-onset Major Depressive Disorder	N/A
Completed	`NCT02452892` - Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)	N/A
Completed	`NCT01407575` - Buprenorphine for Treatment Resistant Depression	Phase 3
Completed	`NCT01583400` - Enhanced Collaborative Depression Treatment in Primary Care: The RESPECT-D-E Trial	N/A
Completed	`NCT01152996` - Safety and Tolerability of Vortioxetine (LuAA21004) - Open Label Extension Study	Phase 3
Enrolling by invitation	`NCT00762866` - Psychiatric Genotype/Phenotype Project Repository
Completed	`NCT00366652` - Study Evaluating the Effects of DVS SR and Duloxetine on the Pharmacokinetics of Desipramine in Healthy Subjects	Phase 3
Completed	`NCT00384033` - Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) In The Treatment Of Major Depressive Disorder	Phase 3
Completed	`NCT00369343` - Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Versus Placebo in Peri- and Postmenopausal Women	Phase 3
Completed	`NCT00149643` - Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence	Phase 2
Completed	`NCT00316160` - Sexual Functioning Study With Antidepressants	Phase 4