View clinical trials related to Depressive Disorder, Major.
Filter by:Research into the mechanisms underlying memory impairment in ECT suggests that its development may be prevented by the administration of certain medications at the time of ECT treatment. For example there are reasons to believe that ketamine, also used as an anaesthetic agent, may have such protective properties. In this clinical study patients undergoing a course of ECT will be offered the opportunity to receive a small dose of ketamine (or a placebo) as part of their anaesthetic at the time of ECT treatment. Mood changes and any memory changes will be evaluated to see if the subjects who received ketamine had less memory side effects than those who did not, while still improving their depression.
To compare the efficacy of Quetiapine SR versus placebo over 8 weeks in unipolar non-psychotic adult outpatients depression and comorbid fibromyalgia. This will be measured by the last observation carried forward (LOCF) mean change from baseline to week 8 on the Hamilton Depression Scale (HAM-D) total score. For the purposes of this study, response regarding improvement in depressive symptoms will be defined as a 50% decrease in HAM-D scores over 8 weeks. Furthermore, proportion of patients achieving remission is defined as an HAM-D total score of 7 at end of treatment. The anxiety comorbid symptoms often associated with major depression will be assessed with the HAM-A (14 items) scale. Proportion of patients responding and achieving remission of anxiety symptoms are defined respectively as a reduction of 50% in the HAM-A total score from baseline and a HAM-A total score of 7 at the end of treatment.
The purpose of this study is to determine the efficacy and safety of once daily vortioxetine (Lu AA21004) in adults with major depressive disorder.
The primary objective is to demonstrate whether the addition of pipamperone 5 mg twice daily (bd) to citalopram, 40 mg daily in patients suffering from MDD will improve the efficacy of citalopram 40 mg in these patients. Secondary objectives are to demonstrate whether the addition of pipamperone 5 mg twice daily (bd) to citalopram, 40 mg daily in patients suffering from MDD: 1. Will increase the rate of resolution of symptoms with citalopram 40 mg. 2. Show the combined product to be safe and tolerable. Patients are scheduled to receive study medication for eight weeks and a final follow-up check will be carried out 28 days after completing the study. All patients will receive active citalopram from baseline and will be randomised to receive either active pipamperone or a placebo equivalent for eight weeks during which time they will attend for 6 study visits.
The purpose of this study is to determine the efficacy and safety of vortioxetine, once daily (QD), in adults with major depressive disorder.
The goal of this study is to begin to test whether or not pioglitazone, an FDA approved medication used to treat high blood sugar, may be safe and effective in treating Major Depressive Disorder (MDD) in patients with comorbid Metabolic Syndrome (METSYN).
The primary purpose of this study is to evaluate the long-term safety and tolerability of Desvenlafaxine Succinate Sustained-Release (DVS SR) in child and adolescent outpatients with major depressive disorder. A secondary aim is to evaluate the efficacy of DVS SR in the treatment of child and adolescent outpatients with major depressive disorder in an exploratory manner.
This is a short-term study to evaluate the efficacy, safety, and tolerability of escitalopram in adult patients (18 to 65 years of age) with moderate to severe depression. Patients completing the study may be eligible to enter a long-term open-label extension study with escitalopram.
tDCS applies a small amount of direct electric current (DC) to the brain by means of two electrodes: the one is an active electrode, localized on the effective site, and the other is a reference electrode, localized on some "silent" part of the body. Anodal transcranial direct current stimulation (tDCS) of the left dorsolateral prefrontal cortex (DLPFC) has been associated with working memory enhancement and improvement of mood. This study will investigate the possible antidepressant effects of tDCS in patients with therapy resistant major depressive episodes.
This is a 12-week, double-blind, placebo-controlled study on the efficacy, tolerability and safety of oral ziprasidone as monotherapy in patients with (major depressive disorder) MDD. The study involves the enrollment of a total of 120 patients with MDD over the course of 12 months across two sites. Outpatients suffering from MDD will be treated with either ziprasidone or with placebo for 12 weeks using the sequential parallel comparison design. In light of the challenge major depressive disorder (MDD) poses to clinicians and patients alike, identifying novel treatments is urgently needed to help further refine the standard of care. Judging by their molecular structure and function, the atypical neuroleptic agents offer possibilities as effective antidepressants. To date, several studies have been reported examining the use of atypical neuroleptic agents as adjunctive therapy (used along with an antidepressant) for MDD. These studies go so far as to suggest that atypical neuroleptic agents have potential for treating MDD. Until now, atypical neuroleptics have been strictly viewed as adjuncts, however, it is quite possible that some of the atypical neuroleptic agents may possess antidepressant properties when used as the lone therapy. The atypical neuroleptic agent ziprasidone, in particular, is an excellent neuroleptic candidate for studying antipsychotic effects on MDD for two principal reasons: its structure makes it favorable for binding to neurotransmitters in the brain and it has fewer side-effects compared to the other drugs in its class. This study will be the first, double blind, placebo-controlled trial of ziprasidone as monotherapy for MDD. If safe and effective as an antidepressant, ziprasidone would represent an additional option for patients with MDD. Potential subjects will be approached during a regularly scheduled clinic visit, upon referral from another physician, or in response to research advertisements. Interested individuals will have the opportunity to review the consent form with family, friends, and other physicians prior to making a final decision regarding study enrollment. Once the subject has given informed consent, the screening process for the study will commence. Subjects will have a screening visit to determine eligibility. The screening visit consists of a medical evaluation, completion of psychological rating scales, physical/neurological exams, electrocardiogram, and the collection of blood and urine. After subjects pass screening, they will be randomized into one of 3 study groups. Subjects will receive either 12 weeks of ziprasidone, 12 weeks of placebo, or 6 weeks of placebo followed by 6 weeks of ziprasidone. Study participants will have a 5 in 8 chance of receiving ziprasidone at some point in the study. Subjects will be closely monitored during the study via 2 phone calls weekly from the study coordinator. The overall safety of the study will also be well scrutinized. The investigators shall identify an independent physician safety monitor, who will be without any affiliation to this study. He/she will be provided all the information necessary to evaluate the study's safety parameters and whether or not they are effective preventative measures. Various psychological assessments will be completed by research subjects at every study visit. This research study is designed to test the safety and/or effectiveness of the investigational use of the drug Ziprasidone that has been approved by the U.S Food and Drug Administration (FDA). While the drug used in the study is FDA-approved for treating schizophrenia and Bipolar disorder I, it is not yet approved for alleviating solely the symptoms of depression.