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Effect of ON-tDCS on Memory Function Improvement and Related Circuits in Stable Depression Patients

Depression Clinical Trial

Official title:
Effect of Transcranial Direct Current Stimulation of the Greater Occipital Nerve on Memory Function Improvement and and the Locus Coeruleus-Noradrenergic Circuits in Stable Depression Patients

Clinical Trial Summary

So far, antidepressant drugs have limited memory improvement. Transcranial direct current stimulation, as a non-invasive and safe neuroregulatory technique, is a new direction to improve memory.In this study, transcranial direct current stimulation of the greater occipital nerve was used to explore the effect of improving memory function in patients with stable depression, and related studies were conducted on the locus coeruleus-noadrenal loop and the functional connection between locus coeruleus, hippocampus and amygdala.

Clinical Trial Description

In this study, a randomized, controlled, double-blind design was adopted. Patients with depression were randomly divided into an intervention group and a control group to receive true or fake tDCS stimulation respectively. Clinical data, memory and other related cognitive function assessment, EEG, resting state fMRI, saliva and blood indicators were collected two weeks before and two weeks after the intervention, and followed up for eight weeks. Finally, data correlation analysis was performed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05634941
Study type Interventional
Source First Affiliated Hospital of Zhejiang University
Contact Huang, Manli, M.D
Phone 13957162975
Email huangmanli@zju.edu.cn
Status Recruiting
Phase N/A
Start date October 1, 2022
Completion date October 1, 2024
View Details
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