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Effect of Individualized Precise TMS on Emotional Blunting in Depression and Its Brain Imaging Mechanism

Depression Clinical Trial

Official title:
Study on the Effect and Brain Influence Mechanism of Individualized Precise Transcranial Magnetic Stimulation Based on Image Analysis on Emotional Blunting in Depression

Clinical Trial Summary

This study aims to explore and investigate the therapeutic effect and mechanism of individualized localization of transcranial magnetic stimulation on emotional blunting of depression, improve the understanding of the mechanism of emotional blunting of depression, order to provide new treatment methods and better curative effects for this disease.

Clinical Trial Description

Depression is a common mental illness. The traditional treatment is medication, but many patients do not respond well to medication and have side effects such as emotional blunting. emotional blunting is a numbness to both positive and negative emotions. It is estimated that about 40% to 60% of depressed patients who use serotonin (5-HT) reuptake inhibitors (SSRIs) or 5-HT and norepinephrine (NE) reuptake inhibitors (SNRIs) have varying degrees of affective retardation. Repetitive transcranial magnetic stimulation (rTMS) is a safe and non-invasive method for the treatment of depression. Its clinical efficacy is related to the accuracy of the stimulation target. How to carry out individualized accurate positioning is of great significance for improving the therapeutic effect. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05555940
Study type Interventional
Source Xijing Hospital
Contact Yuyu Zhang
Phone +8615535849017
Email 782861599@qq.com
Status Recruiting
Phase N/A
Start date October 1, 2022
Completion date June 30, 2024
View Details
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