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Treatment, Emotion, and Neuromodulation of Depression (TREND) Study — TREND  

Depression Clinical Trial

Official title:
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Clinical Trial Summary

The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.

Clinical Trial Description

The study has a longitudinal design in which participants complete a baseline assessment, 20 theta burst stimulation (TBS) sessions, a post-TBS assessment, and a follow-up assessment 4 months later. Ideally, TBS sessions will be delivered twice/day, 5 days/week, for 2 weeks. This procedural design of a shorter treatment duration is based on findings of pattern of improvement and newly developed SAINT protocol. A subset of participants will receive training in enhancing positive affect, with 10 training sessions occurring between pairs of TBS sessions. In this study, "response" to intervention will be defined as a greater than 50% decrease in severity of depression symptoms reported by participants. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05436379
Study type Interventional
Source University of Pittsburgh
Contact Ashley Pogue, B.A.
Phone 4123549297
Email pogueam@upmc.edu
Status Recruiting
Phase N/A
Start date June 17, 2022
Completion date June 30, 2024
View Details
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