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Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease

Depression Clinical Trial

Official title:
Investigating Central Neurophysiologic Correlates of Non-Motor Symptoms of Parkinson's Disease

Clinical Trial Summary

This is a randomized, single-blinded, triple crossover study focused on determining the feasibility of using transcranial magnetic stimulation (TMS) for treatment of Parkinson's disease related autonomic dysfunction and depression. Participants will undergo TMS to three brain regions: medial prefrontal cortex (mPFC) (experimental site), dorsolateral prefrontal cortex (DLPFC) (alternative experimental site), or primary sensory cortex (S1) (control site) in a triple crossover design. Participants will complete symptom questionnaires, neurologic examination and cognitive assessments, and orthostatic vital signs recording before and after each brain stimulation session.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05205772
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Recruiting
Phase N/A
Start date February 1, 2022
Completion date July 30, 2024
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