Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression

Depression Clinical Trial

— MusInDep  

Official title:

Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05143983
• Other study ID #: 2021-A01916-35
• Status: Recruiting
• Phase: N/A
• Start date: February 7, 2022
• Est. completion date: September 1, 2022

Study information

• Verified date: November 2021
• Source: Hôpital le Vinatier
• Contact: Jean-Michel DOREY, MD,PHD
• Phone: 0437915531
• Email: jean-michel.dorey[@]ch-le-vinatier.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Depressed subjects display a cognitive bias of information processing and emotional self-regulation, which reinforces negative experiences more than positive ones, known as the negativity bias. The link between depressive disorder and negativity bias has been much studied in terms of genetic, neurobiology, structural and functional neuroanatomy and cognitive sciences. It has been admitted that depressed subjects show impairment of facial expressions and prosody recognition, and of implicit memory.

Induction of depressive or elated mood with musical excerpts listening in healthy subjects influences facial emotions perception, respectively by reducing or enhancing recognition skills. However, no study to date already explored the interest of music-induced positive mood for alleviating negativity bias in depressed elderly population.

Main objective : to assess the impact of exposure to positive valence musical excerpts, on evaluation of facial emotions intensity, in a population of elderly patients hospitalized for depression, compared to neutral valence music listening.

Secondary objectives : to assess the impact of exposure to positive valence musical excerpts, on facial and vocal emotions recognition, and on implicit memory of faces, compared to neutral valence music listening.

The same methodology is also applied in a sample of control participants over 65 years to study the mood induction effect by music in elderlies.

Description:

The duration of the study, from first to last included subject, is estimated at 6 months, from January to June 2022. Each subject will participate for a period of 5 to 10 days.

Depressed group subjects will be pre-selected from all consecutive patients hospitalized or seen in consultation in geronto-psychiatric ward at Centre Hospitalier Le Vinatier, who agreed to participate in research. Patients will pass a basic cognitive task (MMSE) during the inclusion visit.

Healthy controls will be selected from relatives of patients admitted in Centre Hospitalier Le Vinatier, who agreed to participate in research.

Once included, subjects will be randomized, and will remain blind to study hypotheses until the study end.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: September 1, 2022
• Est. primary completion date: June 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Men and Women between the ages of 18 and 60 years old

• Major depressive episode of moderate to strong intensity, according to DSM-5 criteria, diagnosed by a Psychiatrist for subjects with depression ; GDS < 5 for healthy subjects

• Being fluent in French

Exclusion Criteria:

• - Neurodegenerative disorder

• Cognitive impairments (MMSE<26)

• Sensory loss not sufficiently corrected, compromising the perception of oral instructions or visual or auditory stimuli

• Impairment of awareness or attentional abilities restricting completion of cognitive tasks lasting 40 minutes.

And for Patients with depressive episode:

• Psychotic or catatonic features of current depressive episode

• Comorbid psychiatric disorder other than major unipolar depressive or anxiety disorders

• Current treatment by electroconvulsive therapy

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Behavioral:
• Positive valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excerpts, with positive valence characteristics (fast tempo, major key). They will be told to listen carefully in order to then answer a short questionnaire. The listening will be followed by an liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).
• Neutral valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excepts with neutral valence. They will be told to listen carefully in order to then answer to a short questionnaire. The listening will be followed by a liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

Locations

Country	Name	City	State
France	Centre Hospitalier Le Vinatier	Bron Cedex

Sponsors (1)

Lead Sponsor	Collaborator
Hôpital le Vinatier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Emotional intensity score of facial expressions, rated by participants	This intensity score will be calculated for a subject as the mean of intensity scores (from 1 to 5) attributed to negative faces and reverse intensity scores attributed to positive faces. This will give a "negativity score". The higher this score, the more negative emotions are judged as intense and the less positive emotions are judged as intense. This measurement will be collected by a computerized interface in two different sessions, one for each experimental condition.	up to 9 days
Secondary	Emotions recognition	Percentage of correct answers to facial and vocal emotion recognition	up to 7 days
Secondary	Implicit memory	Percentage of identification of previously presented faces with positive expression	1 day