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Neurocardiac Predictors of Treatment Response to rTMS in Depression — NCP  

Depression Clinical Trial

Official title:
Neuro-cardiac Predictors of Treatment Response to rTMS in Depression: A Mechanistic Study Using Interleaved TMS-fMRI

Clinical Trial Summary

Heartbeat is controlled by the brain and is regular but flexible to change in response to environmental and internal stimuli. This feature is known as heart rate variability (HRV). Major depressive disorder (MDD) has been associated with diminished HRV and this is a reflection of abnormal brain function caused by MDD. Repetitive transcranial magnetic stimulation (rTMS) is a treatment that stimulates specific areas of the brain. The goal of this study is to test the hypothesis that rTMS induces changes in connectivity between the area of the brain stimulated with rTMS and deeper areas in the brain associated to heart rate regulation. 110 patients with TRD will be recruited and will undergo a concurrent TMS-fMRI session before receiving a course of iTBS to the L-DLPFC for 30 sessions at 120% rMT.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05139862
Study type Interventional
Source University of British Columbia
Contact Quincy Beck, B.Sc.
Phone 604-822-7308
Email quincy.beck@ubc.ca
Status Not yet recruiting
Phase N/A
Start date February 1, 2022
Completion date December 1, 2024
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