Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students

Depression Clinical Trial

— VIN2020  

Official title:

Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04706806
• Other study ID #: STUDY00012406
• Status: Completed
• Phase: N/A
• Start date: September 29, 2020
• Est. completion date: November 17, 2020

Study information

• Verified date: January 2021
• Source: Arizona State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The objective of this research is to record mood states and depression levels in healthy college students before and after 4 weeks of daily vinegar ingestion.

Description:

Recent research suggests that fruit and vegetable intake is inversely associated with mood states and depression. Although the mechanism is not known, increased gut fermentation is suspected as changes in gut tryptophan metabolism was noted in these trials. Tryptophan is the precursor to serotonin, the neurotransmitter associated with improved mood state, but other metabolites of tryptophan have been associated with mental wellbeing as well. The main ingredient of vinegar, acetic acid, is the most common metabolite produced during gut fermentation of dietary fiber (mainly from fruits and vegetables) and can also be expected to influence the gut microbiome. It has been reported that vinegar ingestion is linked to a change in tryptophan metabolism in healthy adults consuming vinegar daily for 8 weeks. This study will explore the impact of vinegar ingestion on mood states.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 17, 2020
• Est. primary completion date: November 17, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• college student, non-athlete, no chronic health condition

Exclusion Criteria:

• vegetarians or others adhering to special diet, body mass index >30 kg/m2, pregnancy/lactation, unwilling to ingest vinegar

Related Conditions & MeSH terms

• Depression
• Mood

Intervention

Dietary Supplement:
• apple cider vinegar
2 tablespoons diluted in water taken twice daily with meals
• vinegar pill
one pill taken daily

Locations

Country	Name	City	State
United States	Arizona State University	Phoenix	Arizona

Sponsors (1)

Lead Sponsor	Collaborator
Arizona State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	mood state	Profile of Mood States (POMS) questionnaire score	change from baseline at day 28
Primary	depression	Center for Epidemiologic Studies Depression Scale (CES-D)	change from baseline at day 28