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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT04706806
Other study ID # STUDY00012406
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 29, 2020
Est. completion date November 17, 2020

Study information

Verified date January 2021
Source Arizona State University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The objective of this research is to record mood states and depression levels in healthy college students before and after 4 weeks of daily vinegar ingestion.


Description:

Recent research suggests that fruit and vegetable intake is inversely associated with mood states and depression. Although the mechanism is not known, increased gut fermentation is suspected as changes in gut tryptophan metabolism was noted in these trials. Tryptophan is the precursor to serotonin, the neurotransmitter associated with improved mood state, but other metabolites of tryptophan have been associated with mental wellbeing as well. The main ingredient of vinegar, acetic acid, is the most common metabolite produced during gut fermentation of dietary fiber (mainly from fruits and vegetables) and can also be expected to influence the gut microbiome. It has been reported that vinegar ingestion is linked to a change in tryptophan metabolism in healthy adults consuming vinegar daily for 8 weeks. This study will explore the impact of vinegar ingestion on mood states.


Recruitment information / eligibility

Status Completed
Enrollment 25
Est. completion date November 17, 2020
Est. primary completion date November 17, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - college student, non-athlete, no chronic health condition Exclusion Criteria: - vegetarians or others adhering to special diet, body mass index >30 kg/m2, pregnancy/lactation, unwilling to ingest vinegar

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
apple cider vinegar
2 tablespoons diluted in water taken twice daily with meals
vinegar pill
one pill taken daily

Locations

Country Name City State
United States Arizona State University Phoenix Arizona

Sponsors (1)

Lead Sponsor Collaborator
Arizona State University

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary mood state Profile of Mood States (POMS) questionnaire score change from baseline at day 28
Primary depression Center for Epidemiologic Studies Depression Scale (CES-D) change from baseline at day 28
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