Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression

Depression Clinical Trial

Official title: Repeated Partial Sleep Deprivation to Augment SSRI Response in Depression

Status Completed

Clinical Trial Summary

The purpose of the study is to determine whether changing sleep patterns improves response to an antidepressant medication.

Clinical Trial Description

Depression is common and associated with social and economic costs. Although antidepressant medications are an effective treatment for depression, it can take as long as 6-8 weeks before symptoms improve, and 20-35% of individuals who use antidepressants still experience depression symptoms.

New treatments that accelerate response to antidepressants are important to reduce the burden of depression. The objectives of the proposed study are (1) to evaluate the effects of partial sleep deprivation compared to no sleep deprivation for improving response to 8 weeks of fluoxetine 20-40 mg treatment and (2) to examine the underlying sleep mechanisms of treatment response.

Participants who are eligible for the study will be randomly assigned to one of three sleep schedules for a 2-week period while taking fluoxetine: no sleep deprivation (8 hours time in bed), late bedtime (6 hours time in bed, with 2 hour bedtime delay) or early risetime (6 hours time in bed, with 2 hour advancement of rise time). Participants will spend a total of 7 nights in our sleep laboratory and will be followed on fluoxetine for an 8-week period. ;

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Sleep Deprivation

• NCT number: NCT01545843
• Study type: Interventional
• Source: University of Michigan
• Status: Completed
• Phase: Phase 2
• Start date: March 2009
• Completion date: December 2012