Depression Clinical Trial
Official title:
Effectiveness of Medial Frontal Repetitive Transcranial Magnetic Stimulation With Double-Cone-Coil in Patients With Major Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is used to modulate the neuronal excitability in patients with depression. In the present study the investigators will examine whether medial frontal rTMS using a double-cone-coil proves to be superior to conventional high-frequency-rTMS applied to the left-sided prefrontal cortex with a butterfly-coil.
Depression is a common mental disorder that presents with depressed mood, loss of interest,
feelings of guilt or low self-worth, disturbed sleep or appetite, low energy levels and poor
concentration. These problems can become chronic or recurrent and lead to substantial
impairments in an individual's ability to take care of his or her everyday's
responsibilities, at its worst, depression can lead to suicide. Depression can be reliably
diagnosed in primary care. Antidepressant medications and brief, structured forms of
psychotherapy are effective for 60-80% of those affected and can be delivered in primary
care.
In patients with depression the cerebral metabolism is deranged in some specific areas such
as hypoexcitability in frontal cortical areas. High-frequency rTMS of the dorsolateral
prefrontal cortex (DLPFC) has been investigated for the treatment of hypoexcitability
disorders. Mild antidepressant effects of rTMS applied to the left sided dorsolateral
prefrontal cortex (DLPFC) using a standard butterfly coil can possibly be increased by a
different stimulation protocol over the medial frontal cortex using a double-cone-coil.
First hints to effectiveness of this treatment arise from case reports and therefore need
replication and comparability to conventional stimulation protocols. In the present study
the investigators will examine whether medial frontal rTMS using a double-cone-coil proves
to be more effective to conventional high-frequency-rTMS applied to the left-sided
prefrontal cortex with a butterfly-coil.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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