Psychophysiological Correlates of Mindfulness Based Cognitive Therapy (MBCT) in Recurrent Depression

Depression Clinical Trial

— MBCT & EEG  

Official title:

Psychophysiological Correlates of Mindfulness and Attention in Recurrent Depression and Healthy Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00974077
• Other study ID #: HA1399/16-1
• Status: Completed
• Phase: N/A
• First received: September 9, 2009
• Last updated: December 19, 2014
• Start date: September 2008
• Est. completion date: July 2011

Study information

• Verified date: December 2014
• Source: University Hospital Tuebingen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The study investigates cognitive attention, rumination and psychophysiological (EEG) processes in healthy subjects and remitted patients with at least three previous depressive episodes. The investigators expect that Mindfulness Based Cognitive Therapy prevents future depressive episodes and has influence on cognitive and psychophysiological measures.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: July 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• recurrent depression with at least 3 previous MD-episodes, currently remitted (no symptoms)

Exclusion Criteria:

• current depression

• lifetime schizophrenia

• bipolar or schizoaffective disorder

• any neurological disorders

• other psychopathology during last 3 years

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Depression
• Depressive Disorder

Intervention

Behavioral:
• Mindfulness Based Cognitive Therapy
Group treatment over 8 weeks with training in meditation, stress regulation, shift attention, stay present, in addition with cognitive and behavioral strategies (following Williams et al. Manual 2002)

Other:
• Waiting List Control
Patients receive MBCT with a delay of 6 months.

Locations

Country	Name	City	State
Germany	Department of Psychology University of Tuebingen	Tuebingen

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital Tuebingen

Country where clinical trial is conducted

Germany, 

References & Publications (2)

Bostanov V, Keune PM, Kotchoubey B, Hautzinger M. Event-related brain potentials reflect increased concentration ability after mindfulness-based cognitive therapy for depression: a randomized clinical trial. Psychiatry Res. 2012 Oct 30;199(3):174-80. doi: — View Citation

Keune PM, Bostanov V, Hautzinger M, Kotchoubey B. Approaching dysphoric mood: state-effects of mindfulness meditation on frontal brain asymmetry. Biol Psychol. 2013 Apr;93(1):105-13. doi: 10.1016/j.biopsycho.2013.01.016. Epub 2013 Feb 11. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relapse (MDE)		12 month	No
Secondary	Electroencephalography (EEG)		6 month	No