Depression Clinical Trial
Official title:
Translating Affective Science to Predict Outcomes of Behavioral Treatment for MDD
This study will determine how people with depression differ from healthy people in brain activity and interpreting emotions, both before and after receiving a psychotherapy treatment.
Major depressive disorder is a serious form of depression that may be treated with
psychotherapy. However, up to 40% of adults with depression do not show reduced symptoms when
treated with cognitive therapy or behavioral activation (BA), two common forms of
psychotherapy. Certain indicators are generally linked with a successful outcome of
psychotherapy—demographic and clinical characteristics, comorbidity, and treatment
adherence—but no factors reliably predict outcomes of psychotherapy in individuals. This
study will test whether two characteristics related to the way people process emotions,
affective asymmetry and affective reactivity, can predict whether people with depression will
improve with BA therapy.
Both depressed and healthy participants will be recruited for this study. Participation in
this study will last 31 weeks. All participants will complete baseline assessments at Weeks 1
and 2. Depressed participants will then begin receiving 16 weekly sessions of BA therapy. All
participants will be assessed again after 8, 16, 17, and 28 weeks. Assessments will include
the following: a urine toxicology screening; interviews on mental and physical health, family
and childhood experiences, and current mood and functioning; computer tasks; recordings of
electroencephalography (EEG) activity; recordings of reaction to a startle probe; recordings
of electromyography (EMG) activity; recordings of electrodermal activity (EDA); and
measurement of blood pressure.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05777044 -
The Effect of Hatha Yoga on Mental Health
|
N/A | |
| Recruiting |
NCT04977232 -
Adjunctive Game Intervention for Anhedonia in MDD Patients
|
N/A | |
| Recruiting |
NCT04680611 -
Severe Asthma, MepolizumaB and Affect: SAMBA Study
|
||
| Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
| Completed |
NCT04512768 -
Treating Comorbid Insomnia in Transdiagnostic Internet-Delivered Cognitive Behaviour Therapy
|
N/A | |
| Recruiting |
NCT03207828 -
Testing Interventions for Patients With Fibromyalgia and Depression
|
N/A | |
| Completed |
NCT04617015 -
Defining and Treating Depression-related Asthma
|
Early Phase 1 | |
| Recruiting |
NCT06011681 -
The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
|
||
| Completed |
NCT04476446 -
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
|
Phase 3 | |
| Recruiting |
NCT02783430 -
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
| Completed |
NCT04598165 -
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal Support
|
N/A | |
| Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
| Recruiting |
NCT05956912 -
Implementing Group Metacognitive Therapy in Cardiac Rehabilitation Services (PATHWAY-Beacons)
|
||
| Completed |
NCT05588622 -
Meru Health Program for Cancer Patients With Depression and Anxiety
|
N/A | |
| Recruiting |
NCT05234476 -
Behavioral Activation Plus Savoring for University Students
|
N/A | |
| Active, not recruiting |
NCT05006976 -
A Naturalistic Trial of Nudging Clinicians in the Norwegian Sickness Absence Clinic. The NSAC Nudge Study
|
N/A | |
| Enrolling by invitation |
NCT03276585 -
Night in Japan Home Sleep Monitoring Study
|
||
| Completed |
NCT03167372 -
Pilot Comparison of N-of-1 Trials of Light Therapy
|
N/A | |
| Terminated |
NCT03275571 -
HIV, Computerized Depression Therapy & Cognition
|
N/A |