ECT/Succinylcholine: Biochemical, Serum and Cardiovascular Changes

Depression Clinical Trial

Official title:

The Muscle Biochemical, Serum Potassium and Cardiovascular Changes After Succinylcholine in Patients Undergoing Electroconvulsive Therapy.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00750906
• Other study ID #: H898-32701
• Status: Terminated
• Start date: October 2008
• Est. completion date: April 30, 2015

Study information

• Verified date: January 2020
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will be conducted to determine the pharmacodynamics, cardiovascular and biochemical effects of succinylcholine when given during electroconvulsive therapy. (ECT). This is a single center, prospective, study in patients who will be receiving ECT as indicated and prescribed by their psychiatrist. The study will be performed twice on each patient, 48-72 hours apart during consecutively scheduled ECT procedures.

Description:

Patients will receive the anesthetic that is traditionally given which includes appropriate doses of succinylcholine. Serum potassium and creatinine phosphokinase (CK) levels will be determined pre and post anesthesia; serum and urine myoglobin will be determined post anesthesia. Vital signs data [i.e., heart rate (arrhythmias) and arterial blood pressure] will be compared pre and post anesthesia. In addition patients will be asked about the presence of muscle pain (myalgia) 1 hour before discharge from the recovery room and the following day post ECT.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 13
• Est. completion date: April 30, 2015
• Est. primary completion date: April 30, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. A male or non-pregnant female aged 18 years and older

2. American Society of Anesthesiologists physical status 1, 2, 3

3. Scheduled to undergo electroconvulsive therapy under general anesthesia

4. Have given written informed consent

Exclusion Criteria:

1. Pregnant or nursing

2. Any patient in the study investigators opinion who may not be suitable for research.

Related Conditions & MeSH terms

• Depression

Locations

Country	Name	City	State
United States	University of California San Francisco	San Francisco	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, San Francisco

Country where clinical trial is conducted

United States,