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NCT00585455 Clinical Trial

Vascular Effects of Sertraline in Heart Failure

Depression Clinical Trial

Official title:
Effects of Chronic Sertraline Hydrochloride Administration on Vascular Endothelial and Autonomic Function in Patients With Chronic Heart Failure

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT00585455
Other study ID # 0410027131
Secondary ID
Status Terminated
Phase N/A
First received December 22, 2007
Last updated July 22, 2009
Start date January 2006
Est. completion date July 2009

Study information
Verified date July 2009
Source Yale University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression

Recruitment information / eligibility
Status Terminated
Enrollment 4
Est. completion date July 2009
Est. primary completion date July 2009
Accepts healthy volunteers No
Gender Both
Age group 21 Years and older
Eligibility Inclusion Criteria:

- Chronic heart failure with LVEF<40%, age >21 years

- Depression requiring medical treatment with sertraline

Exclusion Criteria:

- Known intolerance of sertraline

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Drug:
• sertraline
open label 25-50 mg daily as tolerated

Locations
Country Name City State
United States Yale University School of Medicine New Haven Connecticut

Sponsors (2)
Lead Sponsor Collaborator
Yale University Pfizer

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Brachial artery flow-mediated dilation 2 months No
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