Depression Clinical Trial
Official title:
Phase Four Double-Blind Randomized Comparative Study on Thestudy on the Efficacy of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism
The aim of the present study was to examine the influence of memantine, a noncompetitive NMDA receptor blocker, in depression co-morbid with long term alcohol heavy use comparing to SSRI-inhibitor, escitalopram. Second goal is to compare their influence to cognitive tasks and the third goal is to follow up alcohol-use with these two medicines.
Context Depression is common clinical problem among alcoholics and its treatment has no
standard and is controversy. Glutamate NMDA-receptors may mediate the effects of long term
alcohol related depression and thus the NMDA-receptor modulator memantine could have effects
on it.
Objectives The preliminary aim of this study was to identify possible new treatment for
depression of alcoholics and compare the efficacy of escitalopram and memantine in co-morbid
depression of alcoholism.
Design and setting Double-blind, randomized, naturalistic study, 26-week trial on alcohol
dependent outpatients.
Participants Eighty alcohol dependent depressive adults
Intervention Subjects were randomized 1:1 to receive memantine or escitalopram 20 mg per
day. During the study the patient received routine psychosocial treatment at A-Clinic. No
concomitant intervention on alcohol consumption and no imposed treatment goals. The patients
were met weekly in first month, then after 3 and 6 months.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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