Genetics of Recurrent Early Onset Major Depression

Depression Clinical Trial

Official title:

Genetics of Recurrent Early Onset Major Depression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00260182
• Other study ID #: R01MH061686-02
• Secondary ID: R01MH061686-02R0
• Status: Completed
• Start date: October 2005
• Est. completion date: June 2009

Study information

• Verified date: April 2019
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will identify specific genes that may cause a predisposition to depression in some families.

Description:

Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression.

Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study.

For information on a related study please follow this link:

http://clinicaltrials.gov/show/NCT00005914

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2302
• Est. completion date: June 2009
• Est. primary completion date: June 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 70 Years

Eligibility

Inclusion Criteria:

• History of recurrent major depression

• Has a parent or sibling with a history of recurrent major depression

• Depression began before the age of 31

Exclusion Criteria:

• Bipolar I (manic-depressive) disorder

• Schizophrenia

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Depressive Disorder, Major

Locations

Country	Name	City	State
United States	Johns Hopkins University	Baltimore	Maryland
United States	Rush University Medical Center	Chicago	Illinois
United States	University of Iowa	Iowa City	Iowa
United States	Columbia University/New York State Psychiatric Institute	New York	New York
United States	Stanford University	Palo Alto	California
United States	Howard University	Washington	District of Columbia

Sponsors (2)

Lead Sponsor	Collaborator
Stanford University	National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Major depressive disorder diagnosis	The study will correlate genome-wide SNP genotypes with case vs. control status, defined by presence or absence of major depressive disorder.; Participants will attend an interview regarding personal and family history of psychiatric disorders, and give a blood specimen. Genotypes from blood samples will be studied for association with presence of major depressive disorder.	One patient interview session (typically 2 hours), and blood draw (10-20 minutes)

External Links

•   Click here for the Stanford University study web page