Depression Clinical Trial
Official title:
Accelerated Transcranial Magnetic Stimulation for Depression
The purpose of this study is to determinate if accelerated rTMS treatment over 1.5 days is effective for ameliorating depression in Parkinson's disease.
Objective: The goal of this study is to investigate a new approach to administering
repetitive transcranial magnetic stimulation (rTMS) in patients with refractory depression.
(Please Note: The original requirement for comorbid Parkinson's disease has been dropped
from this study).
Research Plan: This inpatient study will provide an initial test for the hypothesis that
accelerated rTMS is an effective treatment for depression. Followup testing will help
delineate the time course of response.
Methods: The rTMS treatment site over left dorsolateral prefrontal cortex will be 5.5cm
anterior to the hand motor area. Treatments consisting of 1000 total pulses at 10 Hz and
100% motor threshold will be administered hourly for 1.5 days, totaling 15 sessions. A
comprehensive test battery will be administered just before and after treatment, at 3 weeks,
and at 6 weeks after treatment.
Clinical Relevance: We expect that accelerated rTMS treatments will lessen the degree of
depression to the same extent as rTMS treatments of longer duration, but far more rapidly. A
much shorter hospitalization would be more easily tolerated. In addition, reducing the
duration of hospitalization substantially reduces burdens and costs to hospital, staff, and
caregivers, while more rapidly enhancing function and quality of life.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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