Depression Clinical Trial
Official title:
Maintaining HIV Risk Reduction Among Needle Exchangers
This study will evaluate the effectiveness of antidepressant medication treatment in reducing HIV risk behaviors in intravenous drug users with depression.
Depression and injection drug use often come hand-in-hand. This is especially true in
populations with limited access to mental health care and with a high risk of illness and
HIV transmission. Depressed injection drug users in these populations usually continue their
drug use for extended periods of time, thereby further promoting the spread of HIV. This
cycle has created a significant public health problem. It is necessary to explore new
approaches to facilitate and maintain long-term behavior changes within this population.
This study will evaluate the effectiveness of treatment with antidepressant medications in
reducing HIV risk behaviors in depressed intravenous drug users.
Participants in this open label study will be randomly assigned to receive either
antidepressant treatment or no treatment. Participants in the treatment group will meet with
a psychiatrist monthly for 12 months. Based on psychiatric evaluations and participants'
medical histories, doctors will prescribe an appropriate antidepressant medication or a
combination of medications. Participants in the treatment group may also receive referrals
for other services if necessary. Participants assigned to receive no treatment will be
contacted at Months 3 and 9 to verify their contact information; they will also receive any
necessary referrals. All participants will partake in interviews at baseline and Months 6
and 12 to assess changes in HIV risk behavior and depressive symptoms.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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