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VISN 20: Prophylactic Treatment of Interferon-Induced Depression in Hepatitis C Patients

Depression Clinical Trial

Official title:
VISN 20 Prophylactic Treatment of IFN-Induced Depression in Hepatitis C

Clinical Trial Summary

The purpose of this study is to learn more about the effects of interferon and ribavirin combination therapy in people with Hepatitis C. The specific aims are:

- To assess how often depressive symptoms occur in patients taking combination alpha interferon plus ribavirin or pegylated interferon plus ribavirin therapy for Hepatitis C, when depressive symptoms occur, and how severe the depressive symptoms are when they do occur;

- To identify potential predictors for the development of depressive symptoms;

- To identify if citalopram, an antidepressant medication, can prevent or lessen the severity of depressive symptoms brought about by interferon therapy.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00108563
Study type Interventional
Source VA Office of Research and Development
Contact
Status Completed
Phase Phase 4
Start date October 2003
Completion date September 2006
View Details
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