Therapy for Depressed Elders With Thought Problems

Depression Clinical Trial

Official title:

PST in Geriatric Depression With Executive Dysfunction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00052091
• Other study ID #: H7472-19384-8
• Secondary ID: R01MH063982DATR
• Status: Completed
• Phase: Phase 3
• First received: January 22, 2003
• Last updated: January 25, 2018
• Start date: September 2002
• Est. completion date: March 2008

Study information

• Verified date: January 2018
• Source: University of Washington
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will compare the effectiveness of Problem Solving Therapy and Brief Supportive Therapy in treating elderly patients with major depression and thought problems.

Description:

Patients who suffer from a combination of major depression and executive dysfunction symptoms often respond poorly to treatment with antidepressants. It is important, therefore, to find effective alternative therapies to treat these symptoms.

Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 221
• Est. completion date: March 2008
• Est. primary completion date: March 2008
• Accepts healthy volunteers: No
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Nonpsychotic, unipolar major depression

• Cognitive impairment

• English speaking

Exclusion Criteria:

• High suicide risk

• Dementia

• Acute or severe medical illness

• Current psychotherapy

Related Conditions & MeSH terms

• Cognition Disorders
• Depression
• Depressive Disorder

Intervention

Behavioral:
• Problem Solving Therapy
A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
• Brief Supportive Therapy
A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.

Locations

Country	Name	City	State
United States	University of California at San Francisco	San Francisco	California
United States	Weill Medical College of Cornell University	White Plains	New York

Sponsors (2)

Lead Sponsor	Collaborator
University of Washington	National Institute of Mental Health (NIMH)

Country where clinical trial is conducted

United States, 

References & Publications (2)

Alexopoulos GS, Raue PJ, Kiosses DN, Mackin RS, Kanellopoulos D, McCulloch C, Areán PA. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch Gen Psychiatry. 2011 Jan;68( — View Citation

Areán PA, Raue P, Mackin RS, Kanellopoulos D, McCulloch C, Alexopoulos GS. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry. 2010 Nov;167(11):1391-8. doi: 10.1176/appi.ajp.2010 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hamilton Rating Scale for Depression		Measured at screening, weeks 1 through 12, and week 36