Therapy for Depression With Co-occurring Panic or Anxiety Symptoms

Depression Clinical Trial

Official title:

Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00051207
• Other study ID #: R21MH061948
• Secondary ID: DSIR AT-AS
• Status: Completed
• Phase: Phase 1/Phase 2
• First received: January 7, 2003
• Last updated: June 21, 2013
• Start date: November 2002
• Est. completion date: August 2005

Study information

• Verified date: December 2007
• Source: University of Pittsburgh
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.

Description:

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: August 2005
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

• History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.

• History of schizophrenia or schizoaffective disorder.

• Organic affective syndrome.

• Unspecified functional psychosis.

• Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.

• Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.

• DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.

• Inpatient treatment due to suicide risk or psychotic symptoms.

• Index episode secondary to the effect of medically prescribed drugs.

• Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.

• Medical illness that would interfere with the best treatment strategy for the potential participant.

• Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.

• Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Anxiety Disorders
• Depression
• Depressive Disorder
• Disease
• Panic Disorder

Intervention

Behavioral:
• Interpersonal Psychotherapy (IPT)

• IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)

Locations

Country	Name	City	State
United States	Western Psychiatric Institute and Clinic - Depression and Manic Depression Program	Pittsburgh	Pennsylvania

Sponsors (1)

Lead Sponsor	Collaborator
University of Pittsburgh

Country where clinical trial is conducted

United States,