Power Training in Older Multiple Sclerosis Patients — POTOMS  

Multiple Sclerosis Clinical Trial

Official title: Power Training in Older Multiple Sclerosis Patients

Status Recruiting

Clinical Trial Summary

The study seeks to investigate whether 24 weeks of power training has neuroprotective effects in older PwMS. Additional purposes are to examine the effects of 24 weeks power training on physical function, cognitive function and neuromuscular function. Further, it is investigated whether the potential effects of power training are maintained after 24 weeks of follow-up.

Clinical Trial Description

Over the past 3-4 decades, the lifespan among people with multiple sclerosis (MS) has increased substantially. Today more than one-third of all people with MS are 60 years or older. With advanced age, people with MS are more likely to have impairments in cognitive and physical function.

Positive adaptations within the nervous system (~neuroplasticity) have been shown to occur in people with MS following periods of resistance training (RT). This resembles the observations in young and old healthy individuals. Moreover, a specific type of RT termed power training appears to be particularly beneficial, as it emphasizes an explosive concentric phase of muscle contraction. This taxes the nervous system to a very high extent. As a result, power training has been shown to improve several aspects that rely on the nervous system in older individuals without MS. These aspects include cognition, neuromuscular function, and physical function.

The investigators speculate that older people with MS would also benefit. However, no studies have looked into the effects of power training in older people with MS. ;

Related Conditions & MeSH terms

• Aging
• Autoimmune Diseases
• Autoimmune Diseases of the Nervous System
• Demyelinating Autoimmune Diseases, CNS
• Demyelinating Diseases
• Healthy Aging
• Multiple Sclerosis
• Nervous System Diseases
• Sclerosis

• NCT number: NCT04762342
• Study type: Interventional
• Source: University of Aarhus
• Contact: Tobias Gaemelke, MSc
• Phone: +45 28264508
• Email: gaemelke@ph.au.dk
• Status: Recruiting
• Phase: N/A
• Start date: December 7, 2020
• Completion date: August 28, 2024