Clinical Trials Logo
  1. Home
  2. Cytopenia
  3. NCT06285825

A Pilot Study of Emapalumab for the Treatment of CAR T-Cell Therapy-Associated Prolonged Cytopenia

Cytopenia Clinical Trial

Official title:
A Pilot Study of Emapalumab for the Treatment of CAR T-Cell Therapy-Associated Prolonged Cytopenia

Clinical Trial Summary

To look at the safety and effectiveness of emapalumab for the treatment of prolonged severe cytopenia in participants with LBCL who receive CART.

Clinical Trial Description

Primary Objectives: - To evaluate the efficacy of emapalumab for the treatment of prolonged severe cytopenia in participants with LBCL who receive CART. Secondary Objectives: - To evaluate safety and tolerability of emapalumab for the treatment of prolonged severe cytopenia in participants with LBCL who receive CART. Exploratory Objective: - To investigate biomarkers of response and resistance to emapalumab for the treatment of prolonged severe cytopenia in participants with LBCL who receive CART. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06285825
Study type Interventional
Source M.D. Anderson Cancer Center
Contact Paolo Strati, MD
Phone (713) 745-1776
Email pstrati@mdanderson.org
Status Not yet recruiting
Phase Early Phase 1
Start date July 31, 2024
Completion date August 22, 2028
View Details
See also
  Status Clinical Trial Phase
Completed NCT02104440 - Clinical Trial In The Treatment Of Allogeneic Post-Transplant Cytopenias With Sequential Infusion Of Allogeneic Mesenchymal Cells Expanded In Vitro Phase 2
Active, not recruiting NCT03682029 - Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies N/A
Recruiting NCT03026751 - Improving Diagnosis in Idiopathic Cytopenia Using Gene Sequencing N/A
Recruiting NCT06430788 - A Study of Emapalumab for Pediatric Aplastic Anemia Phase 2
Recruiting NCT04873102 - Danazol for Treatment of Cytopenias in Patients With Cirrhosis Phase 2
Active, not recruiting NCT06276036 - Autoimmune Cytopenias as a Sign of Primary Immunodeficiency. N/A
Terminated NCT03733249 - Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study Phase 1/Phase 2
Recruiting NCT02958462 - Pre-myeloid Cancer and Bone Marrow Failure Clinic Study N/A
Recruiting NCT05236764 - Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion N/A
Recruiting NCT04741945 - Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS Phase 2
Completed NCT01928537 - Efficacy and Safety of IV Rigosertib in MDS Patients With Excess Blasts Progressing After Azacitidine or Decitabine Phase 3
Recruiting NCT04419649 - A Study of KER-050 to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes Phase 2
Completed NCT04070612 - National Prospective Cohort for Monitoring Children With Severe Autoimmune Cytopenia.
Active, not recruiting NCT03301168 - Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant Phase 1/Phase 2
Terminated NCT02065869 - Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant Phase 1/Phase 2
Completed NCT00367588 - Low Bacterial Diet in Patients With Cytopenia N/A