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National Prospective Cohort for Monitoring Children With Severe Autoimmune Cytopenia. — BIOCEREVANCE  

Cytopenia Clinical Trial

Official title:
National Prospective Cohort for Monitoring Children With Severe Autoimmune Cytopenia

Clinical Trial Summary

This study aims to study prospectively the clinical and paraclinical evolution and prognostic factors of autoimmune haemolytic anemias, Evans syndromes and chronic immunological thrombocytopenic purpura of children in France.

Clinical Trial Description

These autoimmune haematological diseases are rare diseases affecting the child, often very young, and serious and potentially life-threatening. International literature data are scarce, and include individual cases or small series.

They do not allow to determine an optimal therapeutic strategy in case of escape from the first-line treatments. Existing treatments (long-term corticosteroid therapy, immunoglobulins, splenectomy, immunosuppressants, chemotherapies, and more recently anti-CD20 antibodies) are inconsistently effective, and often associated with serious side effects.

The seriousness of these diseases, the therapeutic difficulties, and the absence of a targeted research project in France, led to the implementation of this study.

This study aims to study prospectively the clinical and paraclinical evolution and prognostic factors of autoimmune haemolytic anemias, Evans syndromes and chronic immunological thrombocytopenic purpura of children in France. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04070612
Study type Observational
Source University Hospital, Bordeaux
Contact
Status Completed
Phase
Start date April 4, 2007
Completion date June 8, 2012
View Details
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