Covid19 Clinical Trial
Official title:
Low Dose Radiotherapy as Antinflammatory Treatment for COVID-19 Pneumonitis
SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to
its high rate of infection and the high morbidity and mortality.
The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting
the immune response. Low dose radiotherapy (LD-RT) (≤ 100 cGy) induces an anti-inflammatory
response, lowering levels of pro-inflammatory cytokines such as IL-1β or inhibit leukocyte
recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid
clinical improvement (within the first week), as well as a reduced mortality (from around 30%
to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit
against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of
LD-RT for SARS-CoV-2.
n/a
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