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Clinical Trial Summary

Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known.

The investigators will explore patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected.

The investigators will determine whether this persistance varies according to

- the severity of the Covid-19

- a treatment by steroids during the covid-19. This will help to anticipate whether a second wave of infection is possible in a non-naive population.


Clinical Trial Description

Covid-19 is associated with the onset of anti-SARS-CoV-2 antibodies; in a majority of patients, neutralizing antibodies are detected. However, the long-term persistence of such protective antibodies is not known.

The investigators will explore adult patients with a proven Covid-19 (positive PCR) 6 and 12 months after the diagnosis to determine whether neutralizing antibodies are still detected.

The investigators will determine whether this persistance varies according to

- the severity of the Covid-19 (3 groups: no oxyegn therapy; oxygen therapy of less than 3L/min; oxygen therapy of 3L/min or more)

- a treatment by steroids during the covid-19. Immunocompromised patients will be excluded. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04543006
Study type Interventional
Source University Hospital, Grenoble
Contact Olivier Epaulard, MD,PhD
Phone 0033476765291
Email oepaulard@chu-grenoble.fr
Status Not yet recruiting
Phase N/A
Start date September 8, 2020
Completion date December 31, 2021

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