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NCT05137249 Clinical Trial

The Glycocalyx in COVID-19 Patients. A Pilot Study

COVID-19 Clinical Trial

— Glycovid-19  

Official title:
The Glycocalyx in COVID-19 Patients. A Pilot Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05137249
Other study ID # EK Nr: 1590/2020
Secondary ID
Status Completed
Phase
First received
Last updated
Start date December 1, 2020
Est. completion date May 1, 2021

Study information
Verified date November 2021
Source Medical University of Vienna
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS. We aim to generate first hints regarding the impact of covid-19 disease on the (damage) of the endothelial glycocalyx. Furthermore, we want to investigate the potential coagulopathies, which go along with shedding of the glycocalyx. The detection of and the relation between the severity of the disease, as well as the extent of the glycocalyx damage during the observational period, as well as the hemostatic alterations, are aim of the study.

Description:

The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS. We aim to generate first hints regarding the impact of covid-19 disease on the (damage) of the endothelial glycocalyx. Furthermore, we want to investigate the potential coagulopathies, which go along with shedding of the glycocalyx. The detection of and the relation between the severity of the disease, as well as the extent of the glycocalyx damage during the observational period, as well as the hemostatic alterations, are aim of the study.Circulating plasma syndecan-1 is measured as surrogat parameter for the extent of the glycocalyx damage.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date May 1, 2021
Est. primary completion date March 1, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - COVID-19 detected by PCR measures going along with clinical symptoms - age > 18 years Exclusion Criteria: - refusal of study participation

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Austria Medical University of Vienna Vienna

Sponsors (1)
Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome
Type Measure Description Time frame Safety issue
Primary extent of endothelial damage circulating plasma syndecan-1 as surrogat parameter for endothelial damage is measures up to 2 months
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