COVID-19 Infection Clinical Trial
Official title:
Thyroid Function Tests and the Status of Thyroid Autoantibodies in Hospitalized Covid-19 Patients and Their Relationship With White Blood Cells, Neutrophil / Lymphocyte Ratio, c Reactive Protein, Fibrinogen, Procalcitonin, Ferritin and D-dimer
NCT number | NCT04659200 |
Other study ID # | 06122020 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | September 1, 2020 |
Est. completion date | December 7, 2020 |
Verified date | January 2021 |
Source | Bezmialem Vakif University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation through cytokines in various organs of the body, especially the lungs. This cytokine-mediated widespread inflammation can also affect the thyroid gland, causing thyroiditis and impaired thyroid functions. The researchers evaluated thyroid function tests and thyroid autoantibodies in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known thyroid disease. The researchers examined the relationship of thyroid hormones and thyroid autoantibodies to COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer stages in these patients. Researchers compared changes in thyroid hormones and autoantibodies in people without COVID-19 infection and without thyroid disease.
Status | Completed |
Enrollment | 20 |
Est. completion date | December 7, 2020 |
Est. primary completion date | December 5, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | Inclusion Criteria: - To accept research. - Being over the age of 18. - COVID 19 test results to be positive. - Not taking thyroid disease medication before. - Receiving inpatient treatment in the COVID service in the hospital. Exclusion Criteria: - Not accepting research. - Be under the age of 18. - Negative COVID 19 test results for patients. - COVID patients treated as outpatient. - Thyroid disease in the healthy control group. |
Country | Name | City | State |
---|---|---|---|
Turkey | Sabahattin Destek | Fatih | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Bezmialem Vakif University |
Turkey,
Brancatella A, Ricci D, Viola N, Sgrò D, Santini F, Latrofa F. Subacute Thyroiditis After Sars-COV-2 Infection. J Clin Endocrinol Metab. 2020 Jul 1;105(7). pii: dgaa276. doi: 10.1210/clinem/dgaa276. — View Citation
Caron P. Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management. Ann Endocrinol (Paris). 2020 Oct;81(5):507-510. doi: 10.1016/j.ando.2020.09.001. Epub 2020 Sep 18. Review. — View Citation
Mattar SAM, Koh SJQ, Rama Chandran S, Cherng BPZ. Subacute thyroiditis associated with COVID-19. BMJ Case Rep. 2020 Aug 25;13(8). pii: e237336. doi: 10.1136/bcr-2020-237336. — View Citation
van Gerwen M, Alsen M, Little C, Barlow J, Naymagon L, Tremblay D, Sinclair CF, Genden E. Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study. Front Endocrinol (Lausanne). 2020 Aug 18;11:565. doi: 10.3389/fendo.2020.00565. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comparison of thyroid stimulating hormone (TSH) between groups | In the study, serum TSH results of the Covid patient group and non-Covid control groups were recorded and compared statistically. | 90 days | |
Primary | Comparison of free triiodothyronine (fT3) between groups | In the study, serum fT3 results of the Covid patient group and non-Covid control groups were recorded and compared statistically. | 90 days | |
Primary | Comparison of free thyroxine (fT4) between groups | In the study, serum fT4 results of the Covid patient group and non-Covid control groups were recorded and compared statistically. | 90 days | |
Primary | Comparison of anti-thyroid peroxidase (Anti-TPO) between groups | In the study, serum anti-TPO results of the Covid patient group and non-Covid control groups were recorded and compared statistically. | 90 days | |
Primary | Comparison of anti-thyroglobulin (Anti-Tg) between groups | In the study, serum anti-Tg results of the Covid patient group and non-Covid control groups were recorded and compared statistically. | 90 days | |
Primary | White blood cells (WBC) results of Covid 19 patient group | In the study, serum WBC results were recorded in Covid 19 patient groups. | 90 days | |
Primary | Neutrophil / lymphocyte ratio (N/LO) results of Covid 19 patient group | In the study, serum N/LO results were recorded in Covid 19 patient groups. | 90 days | |
Primary | C-reactive protein (CRP) results of Covid 19 patient group | In the study, serum CRP results were recorded in Covid 19 patient groups. | 90 days | |
Primary | Fibrinogen results of Covid 19 patient group | In the study, serum fibrinogen results were recorded in Covid 19 patient groups. | 90 days | |
Primary | Procalcitonin results of Covid 19 patient group | In the study, serum procalcitonin results were recorded in Covid 19 patient groups. | 90 days | |
Primary | Ferritin results of Covid 19 patient group | In the study, serum ferritin results were recorded in Covid 19 patient groups. | 90 days | |
Primary | D-dimer results of Covid 19 patient group | In the study, serum D-dimer results were recorded in Covid 19 patient groups. | 90 days |
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