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NCT04359251 Clinical Trial

Different PEEP Settings of COVID-19 Induced ARDS

COVID-19 Clinical Trial

Official title:
Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04359251
Other study ID # COVID-19 PEEP titration
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 5, 2020
Est. completion date March 25, 2020

Study information
Verified date April 2020
Source Southeast University, China
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Description:

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date March 25, 2020
Est. primary completion date March 25, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- COVID-19 patients with mechanical ventilation

- PO2/FIO2<300mmHg

- ages>18 years

Exclusion Criteria:

- pneumothorax

- pregnant

- hemodynamics is unstable

Study Design

Related Conditions & MeSH terms

  • Acute Lung Injury
  • Acute Respiratory Distress Syndrome
  • COVID-19
  • Mechanical Ventilation Pressure High
  • Respiratory Distress Syndrome, Adult
  • Respiratory Distress Syndrome, Newborn

Intervention

Other:
• Gas exchanges at different PEEP
Gas exchanges measurement at different PEEP
• lung mechanics at different PEEP
lung mechanics measurement at different PEEP
• Hemodynamics changes at different PEEP
Hemodynamics changes measurement at different PEEP

Locations
Country Name City State
China Zhongda Hospital, Southeast University Nanjing Jiangsu

Sponsors (1)
Lead Sponsor Collaborator
Southeast University, China

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Other hemodynamics improvement MAP were compared among three groups 20 minutes
Primary Respiratory system compliance improvement the respiratory system compliance was compared among three groups 20 minutes
Secondary Gas echanges improvement P/Fwere compared among three groups 20 minutes
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