Different PEEP Settings of COVID-19 Induced ARDS

COVID-19 Clinical Trial

Official title:

Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04359251
• Other study ID #: COVID-19 PEEP titration
• Status: Completed
• Phase: N/A
• Start date: March 5, 2020
• Est. completion date: March 25, 2020

Study information

• Verified date: April 2020
• Source: Southeast University, China
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Description:

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: March 25, 2020
• Est. primary completion date: March 25, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• COVID-19 patients with mechanical ventilation

• PO2/FIO2<300mmHg

• ages>18 years

Exclusion Criteria:

• pneumothorax

• pregnant

• hemodynamics is unstable

Related Conditions & MeSH terms

• Acute Lung Injury
• Acute Respiratory Distress Syndrome
• COVID-19
• Mechanical Ventilation Pressure High
• Respiratory Distress Syndrome, Adult
• Respiratory Distress Syndrome, Newborn

Intervention

Other:
• Gas exchanges at different PEEP
Gas exchanges measurement at different PEEP
• lung mechanics at different PEEP
lung mechanics measurement at different PEEP
• Hemodynamics changes at different PEEP
Hemodynamics changes measurement at different PEEP

Locations

Country	Name	City	State
China	Zhongda Hospital, Southeast University	Nanjing	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Southeast University, China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	hemodynamics improvement	MAP were compared among three groups	20 minutes
Primary	Respiratory system compliance improvement	the respiratory system compliance was compared among three groups	20 minutes
Secondary	Gas echanges improvement	P/Fwere compared among three groups	20 minutes