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NCT ID: NCT05438589 Recruiting - Clinical trials for COVID-19 Respiratory Infection

Novel Rapid POC Diagnostics for COVID-19

Start date: April 25, 2022
Phase:
Study type: Observational

This is a prospective, multicentre study in which the diagnostic accuracy of multiple Covid-19 Antigen rapid diagnostic tests will be assessed for COVID-19 case detection using prospectively collected nasal swabs and saliva samples from participants suspected to have Covid-19 infection (with or without symptoms). The study will last approximately 9 months.

NCT ID: NCT05436795 Not yet recruiting - COVID-19 Clinical Trials

A Randomized Controlled Trial of a Digital, Self-testing Strategy for COVID-19 Infection in South Africa.

Start date: July 2022
Phase: Phase 1/Phase 2
Study type: Interventional

With daily COVID-19 infection surges globally, novel diagnostic solutions are needed. As the world opens up to rapidly increasing vaccination coverage and newer variants, there is a need for timely access to at-home COVID-19 testing, or self-testing based out of kiosks, offices, or private spaces. Data on digital strategies are sparse. Using a superiority randomized controlled trial design (open-label, single-blinded), we will aim to evaluate the impact of a digital self-testing strategy offered out of kiosks/private spaces on the turnaround time to test results, proportion of participants initiated on action plans, and new infection detected. We will compare these outcomes to a conventional lab-based strategy. Significance: A digital, portable, self-testing strategy will facilitate rapid self-knowledge of COVID-19 status, and rapid classification into clinical/quarantine/prevention plans. The study will document the impact of a digitally connected self-testing strategy for COVID-19 infection. Upon completion of the strategy, the digital program will be available for global dissemination.

NCT ID: NCT05435027 Recruiting - COVID-19 Clinical Trials

Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)

Start date: February 28, 2022
Phase: Phase 1
Study type: Interventional

The primary objective is to assess the safety and tolerability of samRNA vaccines GRT-R912, GRT-R914, and GRT-R918 when administered as prime and/or boost in healthy adult participants naïve to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV-2 convalescent, previously vaccinated, or non-vaccinated participants, and people living with HIV (PLWH) or HIV-negative.

NCT ID: NCT05423847 Recruiting - Tuberculosis Clinical Trials

Triage UltraSound in Tb Endemic Regions

TrUST
Start date: October 14, 2021
Phase:
Study type: Observational

In Sub-Saharan Africa, lower respiratory tract infections (LRTIs) and tuberculosis (TB) jointly are the leading cause of overall mortality. There is a need to integrate sustainable triage and management strategies into standard care. The TrUST study investigates the utility of point-of-care ultrasound (POCUS) for diagnosis and prognosis of LRTIs in TB endemic regions in the outpatient triage setting. Automated interpretation of POCUS by artificial intelligence (AI) may further standardize and improve its predictive utility as well as facilitate its implementation into usual practice.

NCT ID: NCT05417620 Not yet recruiting - HIV Infections Clinical Trials

Le Kip Kip: A Multi-Layered Cluster Randomized Trial to Change Social Norms and Build Sustainable Demand for PrEP Among Women in South Africa

Start date: June 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the impact of a social media campaign and community engagement activities to promote pre-exposure prophylaxis (PrEP) use among young women and to influence community norms around PrEP in South Africa. To do this, the investigative team will analyze PrEP initiation and retention data from the study's implementing partner, TB HIV Care, a non-profit organization providing PrEP to marginalized young women in South Africa. The effect of the social media campaign and community engagement will be tested using a short duration cluster randomized trial (CRT).

NCT ID: NCT05414786 Recruiting - HIV-1-infection Clinical Trials

A Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644)

Start date: May 26, 2022
Phase: Phase 1
Study type: Interventional

A Phase 1 Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) in HIV-1 Uninfected Adults in Good General Health.

NCT ID: NCT05414097 Not yet recruiting - Cervical Cancer Clinical Trials

Finding Barriers and Designing Solutions to Promote Women s Cancer Screening in South Africa

FIND
Start date: June 2022
Phase:
Study type: Observational

The primary aim of the study explore drivers of cervical cancer screening and barriers contributing to low screening coverage among women in South Africa. Secondary aims are determining preferences for cervical cancer prevention services using a discrete choice experiment and developing a multi-level package of interventions that will address barriers to cervical cancer screening and improve engagement in care among women.

NCT ID: NCT05413811 Not yet recruiting - Cervical Cancer Clinical Trials

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV

ACT2
Start date: August 20, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among the woman with HIV infection.

NCT ID: NCT05413798 Not yet recruiting - Cervical Cancer Clinical Trials

Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa

Start date: August 2022
Phase: N/A
Study type: Interventional

The purpose of this study explores the usefulness of urine samples for cervical cancer screening in human immunodeficiency virus (HIV)-infected women. Cervical cancer occurs when women are infected with the human papillomavirus (HPV), which can cause changes in the cells that lead to cervical precancer and, eventually, cervical cancer if untreated. However, urine HPV testing has not been well validated low- and middle-income country settings, with no data available to guide its use in HIV-infected women.

NCT ID: NCT05413122 Not yet recruiting - HIV Clinical Trials

Evaluating Smoking Cessation Interventions for PWH in South Africa

Tlogela
Start date: September 1, 2022
Phase: Phase 4
Study type: Interventional

The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.