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NCT ID: NCT05053139 Not yet recruiting - Haemophilia A Clinical Trials

A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors

Start date: December 3, 2021
Phase: Phase 3
Study type: Interventional

This study is investigating how Mim8 works compared to other medicines in people with haemophilia A, who either have inhibitors or do not have inhibitors. Mim8 is a new medicine that will be used for prevention of bleeding episodes. Mim8 works by replacing the function of the missing clotting factor VIII (FVIII). When and how often participants will receive Mim8 is dependent on their previous treatment - but is otherwise decided by chance. The study will last for 72-124 weeks (17-29 months) depending on how long participants will be followed before it is decided when they start receiving Mim8 - the period before this is decided is called the 'run-in'. Participants will have 13-17 clinic visits. Mim8 will be injected into a skinfold on the stomach with a thin needle either once a week or once a month.

NCT ID: NCT05047445 Not yet recruiting - COVID-19 Clinical Trials

A First Time in Human Phase 1 Open-Label Study of the COVIDITY Vaccine Administered by Needle-free Injection

Start date: September 2021
Phase: Phase 1
Study type: Interventional

The main objectives of this study are to assess the safety, tolerability and immunogenicity of the candidate SARS-CoV-2 vaccines, COVIDITY, when administered using a needle-free injection device.

NCT ID: NCT05039619 Not yet recruiting - Lupus Nephritis Clinical Trials

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis

POSTERITY
Start date: September 30, 2021
Phase: Phase 2
Study type: Interventional

This phase II, randomized, double-blind, placebo-controlled study is designed to evaluate the safety, efficacy and pharmacokinetics of obinutuzumab in adolescent participants aged 12 to less than 18 with biopsy-confirmed proliferative lupus nephritis (LN).

NCT ID: NCT05037929 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Start date: September 1, 2021
Phase: Phase 2
Study type: Interventional

This study will evaluate the efficacy, safety, and pharmacokinetics of astegolimab in combination with standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or current smokers and have a history of frequent exacerbations.

NCT ID: NCT05022212 Recruiting - HIV Infections Clinical Trials

Phase 2 Trial of LACTIN-V in Women at High Risk of HIV Acquisition

Start date: May 10, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the impact of LACTIN-V, a vaginally administered live biotherapeutic product (LBP) that contains the human L. crispatus CTV-05 strain, on the vaginal microbiome of Lactobacillus-deficient young women in the South African FRESH study who are at high risk for HIV acquisition.

NCT ID: NCT05017324 Not yet recruiting - Clinical trials for Multidrug Resistant Tuberculosis

Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment Trial

SMARTT
Start date: August 15, 2021
Phase: N/A
Study type: Interventional

The primary aim of this pragmatic trial is to determine the effectiveness of a Whole Genome Sequencing (WGS) Drug Sensitivity Testing (DST) strategy to guide individualised treatment of rifampicin resistant tuberculosis (RR-TB) patients. The primary objective is to determine the effectiveness of this WGS DST strategy in patients diagnosed with RR-TB. We will additionally perform an exploratory health economics evaluation of both arms, and will determine the feasibility of the WGS DST strategy.

NCT ID: NCT05016986 Completed - Trauma Clinical Trials

Penetrating Gunshot Injuries at a Single Johannesburg Centre

Start date: January 1, 2008
Phase:
Study type: Observational

A retrospective audit of cardiac penetrating cardiac injuries with specific reference to GSW

NCT ID: NCT05016154 Recruiting - Depression Clinical Trials

Online Psychological Group Interventions

Start date: July 26, 2021
Phase: N/A
Study type: Interventional

The aim is to assess the effectiveness of online group CBT for reducing symptoms of depression and anxiety among university students. The investigators will conduct a four-arm randomised control trial comparing a 10-session online group CBT intervention to three mental health apps (namely SilverCloud guided, SilverCloud unguided, and Mood Flow).

NCT ID: NCT05015959 Completed - Clinical trials for Complication of Surgical and Medical Care, Unspecified

Analysis of Surgical Mortalities Using the Fishbone Model for Quality Improvement

Start date: January 1, 2017
Phase:
Study type: Observational

Retrospective data analysis of mortalities and the evaluation of the quality of care offered, using the Fishbone method.

NCT ID: NCT05013346 Recruiting - Type 1 Diabetes Clinical Trials

Characteristics of Young-onset Diabetes in Sub-Saharan Africa (YODA) Study

YODA
Start date: September 1, 2019
Phase:
Study type: Observational

Type 1 diabetes has been poorly characterised, with very sparse information available in the literature about the characteristics of the disease in Africa. Atypical young onset diabetes is often reported by clinicians in sub-Saharan Africa, including patients who have the phenotype of type 1 diabetes but do not appear to have an absolute insulin requirement. The onset of type 1 diabetes in many sub-Saharan African populations seem to occur at later ages (20s to 40s) than what is generally seen in Caucasian populations. The investigators seek to characterise young-onset insulin treated diabetes (clinically diagnosed type 1 diabetes) in sub-Saharan Africa;