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NCT ID: NCT04336137 Recruiting - Psychotic Disorders Clinical Trials

INTernational REsearch Programme on Psychosis In Diverse Settings

INTREPID II
Start date: May 1, 2018
Phase:
Study type: Observational

INTREPID II aims to investigate variability in incidence, presentation, outcome, and impact of untreated psychotic disorders in three countries - India, Nigeria, and Trinidad - through four interconnected observational studies: 1. Study 1 on Incidence, Presentation, and Risk has the objective to investigate the incidence and presentation of untreated psychotic disorders in each setting and associated risk factors. 2. Study 2 on Course and Outcome has the objective to investigate two-year course and outcome of psychotic disorders and associated factors. 3. Study 3 on Help-seeking and Impact has the objective to investigate (a) help-seeking; and (b) the impact of psychotic disorders on individuals and families, using a combination of quantitative and qualitative approaches. 4. Study 4 on Physical Health has the objective to investigate the types and prevalence of physical health problems and related biological markers.

NCT ID: NCT04233619 Completed - Retinal Disease Clinical Trials

Correlation of Microvascular Ophthalmic Disease With Macrovascular Coronary Artery Disease in Trinidad

EYE-MI TNT
Start date: May 1, 2019
Phase:
Study type: Observational

Coronary artery disease (CAD) is the leading cause of death in Trinidad and Tobago. Early detection and management can help improve morbidity and mortality. Retinal artery microvascular disease has been shown to directly correlate with coronary artery disease. Retinal artery calibre screening via the Optic Coherence Tomography (OCT) will provide a non-invasive method of diagnosing CAD.

NCT ID: NCT04206176 Completed - Clinical trials for Platelet Dysfunction Due to Drugs

The Effects of loW Dose tIcagrelor on Platelet Function Testing in Patients With Stable Coronary arTery Disease

TWIST
Start date: October 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to assess the effects of low dose ticagrelor on platelet function testing in patients with stable coronary artery disease.

NCT ID: NCT04001816 Recruiting - Clinical trials for Bimaxillary Proclination

A Randomized Clinical Trial to Investigate Whether Self Ligating Brackets or Conventional Brackets Are Better for Treating Bimaxillary Proclination

Start date: January 4, 2017
Phase: N/A
Study type: Interventional

The study is a single blind randomised control trial.The patients will be randomly assigned to have conventional brackets placed or self ligating brackets placed. All patients will undergo full Orthodontic records. This will include an Orthodontic assesment, study models relevant xrays (orthopantogram and a cephalomgram) and clinical photos. After records analysis, patients will be given a prophylaxis and oral hygiene instructions. Either 3m Victory Series™ Metal Braces or 3m SmartClip™ SL3 Self-Ligating Braces both bracket types will carry the MBT prescription 0.022 slot height, will be bonded using Transbond™ XT (3M Unitek, Monrovia, California, USA) composite resin according to the manufactuer's instruction. These patients will be recalled at monthly intervals for the duration of treatment time which will be 3 years. A cephalogram will be taken at the end of treatment

NCT ID: NCT03863262 Completed - Depression Clinical Trials

Screening for Depression in cADiovasCular pAtients at a Tertiary Center in Trinidad.

SAD-CAT
Start date: November 8, 2018
Phase:
Study type: Observational

This was an observational study aimed to screen patients with cardiovascular disease for depression in Trinidad and Tobago in a tertiary center and to determine if there is a significant association between patients with symptoms of depression and other comorbidities. Patients (N=1203) were randomly selected from the outpatient cardiology clinics at the Eric Williams Medical Sciences Complex. After fulfilling the inclusion criteria and informed consent were obtained, they were given the case report form which included the Patient Health Questionnaire 9.

NCT ID: NCT03667066 Completed - Clinical trials for Platelet Dysfunction

clOpidogrel "resIstaNce" in a Selected Population of Patients at a Tertiary Cardiovascular Center in Trinidad

POINT
Start date: September 1, 2017
Phase:
Study type: Observational

The aim of this study was to determine the prevalence of clopidogrel resistance among a selected group of patients undergoing elective percutaneous coronary intervention and to observe whether there was any south-Asian (Indo-Trinidadian) predilection for HPR considering the well-established epidemiologic trends for accelerated CAD within this subgroup.

NCT ID: NCT03603249 Completed - Clinical trials for Platelet Dysfunction Due to Drugs

Trimetazidine as an Adjunct to Enhance Clopidogrel Response.

TRACER
Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

Hypothesis: Trimetazidine improves Clopidogrel response in patients. • The investigators postulate that the inhibition of platelet aggregation in response to Clopidogrel may be accentuated by Trimetazidine, i.e. Trimetazidine enhances Clopidogrel response. Null Hypothesis: There is no difference in Clopidogrel response in patients with stable coronary artery disease with adjunctive Trimetazidine.

NCT ID: NCT03258723 Terminated - Diabetes Clinical Trials

Diabetes Prevention With Lifestyle Intervention and Metformin Escalation

LIME
Start date: July 30, 2018
Phase: Phase 4
Study type: Interventional

Specific Aim: Implement an evidence-based diabetes prevention pragmatic trial for high risk pre-diabetic individuals of Caribbean-descent to reduce the incidence of diabetes. Hypothesis: This study seeks to test the hypothesis that implementation of a lifestyle intervention, with escalation to Metformin therapy will lower the incidence of diabetes among the highest risk pre-diabetic individuals of Caribbean-descent.

NCT ID: NCT02979938 Completed - Zika Virus Clinical Trials

Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection

Start date: July 2016
Phase:
Study type: Observational

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of 12 months to observe the presence, viral load and infectivity of Zika virus (ZIKV) in semen over time.

NCT ID: NCT02587806 Recruiting - Clinical trials for Multiple Sclerosis, Relapsing-Remitting

A Study of Autologous Bone Marrow-Derived Mononuclear Stem Cells (BM-MNC) and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS

Start date: February 2015
Phase: Phase 1/Phase 2
Study type: Interventional

STUDY OBJECTIVES: Primary Objective: Assessment of treatment safety based on incidence of any treatment emergent/treatment associated adverse events prior to discharge and at 1, 3, 6 and 12 months post treatment. Secondary objective: Assessment of efficacy at baseline, prior to discharge, 1 month, 3 months, 6 months and 12 months after treatment based on the following: EDSS and 29-item Multiple Sclerosis Impact Scale (MSIS-29), MS Functional Composite (MSFC) consisting of (1) Timed 25-Foot Walk, (2) 9 Hole Peg Test, and (3) Paced Auditory Serial Addition Test and gadolinium-enhanced magnetic resonance imaging (MRI).